Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms

Abstract

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

1 .- 114 . (canceled) 
     
     
         115 . A composition comprising a combination of at least one medium polarity oil having an octanol-water partition coefficient (log P) of 0.5 to 2.0 and at least one antibacterial agent, wherein the concentrations of the at least one medium polarity oil and the at least one antibacterial agent in the composition are at amounts that exhibit synergistic antibacterial activity against bacterial biofilms on biological and non-biological surfaces, and wherein the medium polarity oil is a glyceryl ester. 
     
     
         116 . The composition of  claim 115 , wherein the composition further comprises a pharmaceutical carrier. 
     
     
         117 . The composition of  claim 115 , wherein the antibacterial agent is not a C9-C12 aliphatic alcohol. 
     
     
         118 . The composition of  claim 115 , wherein the antibacterial agent is a silver compound, and wherein the silver compound is silver sulfadiazine, silver nitrate, or silver chloride. 
     
     
         119 . The composition of  claim 118 , wherein the composition comprises a carrier and the carrier is a ringing gel. 
     
     
         120 . The composition of any of  claim 118 , wherein the silver compound is at a concentration of 0.1 to 5% w/w. 
     
     
         121 . The composition of  claim 115 , wherein the antibacterial agent is an iodine compound, and wherein the iodine compound is an iodophor. 
     
     
         122 . The composition of  claim 121 , wherein the iodophor is cadexomer-iodine, and wherein the cadexomer-iodine is at a concentration of 40 to 60% w/w. 
     
     
         123 . The composition of  claim 121 , wherein the iodophor is povidone-iodine, and wherein the povidone-iodine is at a concentration of 1 to 20% w/w. 
     
     
         124 . The composition of  claim 115 , wherein the antibacterial agent is an antibiotic, and wherein the composition comprises a carrier and the carrier is a ringing gel. 
     
     
         125 . The composition of  claim 124 , wherein the antibiotic is an aminoglycoside antibiotic chosen from gentamicin or gentamicin sulfate, and wherein the gentamicin or gentamicin sulfate is at a concentration of 0.1 to 5% w/w. 
     
     
         126 . The composition of  claim 124 , wherein the antibiotic is a polypeptide antibiotic chosen from colistin or colistin sulfate, and wherein the concentration of colistin or colistin sulfate is 0.01 to 2% w/w. 
     
     
         127 . The composition of any of  claim 115 , wherein the glyceryl ester is glyceryl caprylate/caprate. 
     
     
         128 . The composition of  claim 127 , wherein the glyceryl caprylate/caprate is at a concentration of 7 to 40% w/w. 
     
     
         129 . The composition of  claim 115 , wherein the bacterial biofilm is a gram-positive bacterial biofilm. 
     
     
         130 . The composition of  claim 115 , wherein the bacterial biofilm is a gram-negative bacterial biofilm. 
     
     
         131 . The composition of  claim 115 , wherein the biological surface is a chronic wound, and wherein the chronic wound is a diabetic foot ulcer, venous ulcer, arterial ulcer, decubitus ulcer, stasis ulcer, pressure ulcer, or burn. 
     
     
         132 . The composition of  claim 115 , wherein the biological surface is a skin lesion, or mucous membrane lesion, and wherein the skin lesion or mucous membrane lesion, is a blister, ulceration, abrasion, wart, scrape, or infection. 
     
     
         133 . An article of manufacture comprising a surface coated with the composition of  claim 115 . 
     
     
         134 . The article of manufacture of  claim 133 , wherein the article of manufacture is a medical device. 
     
     
         135 . The article of manufacture of  claim 133 , wherein a biofilm is not present on the coated surface. 
     
     
         136 . The article of manufacture of  claim 133 , wherein a biofilm is present on the coated surface. 
     
     
         137 . A method of treating a wound, mucous membrane lesion, or skin lesion infected or contaminated with a bacterial biofilm, the method comprising topically administering to the wound, mucous membrane lesion, or skin lesion a composition of  claim 115 .