Methods for restoration of histamine balance

Abstract

Several embodiments provided herein relate to histamine dosing regimens are and uses of such regimens in the restoration of histamine balance in subjects suffering from, for example, histapenia and/or histadelia. Several embodiments also relate to the use of histamine dosing regimens for the treatment and/or prevention of migraine headaches.

1 . (canceled) 
     
     
         2 . A decreasing histamine dosing regimen comprising in sequential order:
 a) a first dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “first time interval”), wherein the doses decrease in histamine concentration from dose to dose while the administered volume of each dose stays constant; and   b) a second dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “second time interval”), wherein the doses decrease in histamine concentration from dose to dose while the administered volume of each dose stays constant;
 wherein the volume of each histamine dose in the second dosing segment is greater than the volume of each histamine dose in the first dosing segment, and the second time interval is longer than the first time interval. 
   
     
     
         3 . A histamine dosing regimen comprising in sequential order:
 a) a first dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “first time interval”), wherein the histamine concentration varies from dose to dose while the administered volume of each dose decreases; and   b) a second dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “second time interval”), wherein the histamine concentration varies from dose to dose while the administered volume of each dose decreases;   wherein the volume of each histamine dose in the second dosing segment is less than the volume of each histamine dose in the first dosing segment, and the second time interval is longer than the first time interval.   
     
     
         4 . A histamine dosing regimen comprising in sequential order:
 a) a first dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “first time interval”), wherein the histamine concentration varies from dose to dose while the administered volume of each dose remains constant; and   b) a second dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “second time interval”), wherein the histamine concentration varies from dose to dose while the administered volume of each dose remains constant;   wherein the second time interval is longer than the first time interval.