Treatment of lymphangioleiomyomatosis

Abstract

Embodiments disclosed herein provide compositions and methods for treating lymphangioleiomyomatosis (LAM) comprising inhibiting COX overexpression and prostaglandin over production by administering at least one COX inhibitor and/or prostaglandin biosynthetic pathway inhibitors.

1 . A composition comprising at least one a cyclooxygenase (COX) inhibitor and/or an inhibitor of the prostaglandin biosynthetic pathway for the treatment of lymphangioleiomyomatosis (LAM). 
     
     
         2 . The composition of  claim 1 , further comprising rapamycin. 
     
     
         3 . (canceled) 
     
     
         4 . The composition of  claim 1 , further comprising at least one compound selected from the group consisting of SCH-202676 hydrobromide, danusertib (PHA-739358), AZ-960, nicardipine, SB-590885, Thimerosal, ionomycin, U-73343, PAF C16, BX912, and Chlorambucil. 
     
     
         5 . (canceled) 
     
     
         6 . A composition comprising at least one a cyclooxygenase (COX) inhibitor and/or an inhibitor of the prostaglandin biosynthetic pathway and at least one compounds selected from the group consisting of nateglinide, Z-L-Phe chloromethyl ketone, clemastine fumarate, supercinnamaldehyde, practolol, fluvastatin Na, sulindac, BIO, amorolfine, spectinomucin, sibutramine HCl, nelfinavir mesylate, moroxydine HCl, nicotine ditartrate, trequinsin, megluime, tizanidine HCl, CGP-74514A hydrochloride, tioconazole, afatinib, kasugamycin, flupentixol, fluphenazine, mephenytoin, aminoglutethimide, betaxolol hydrochloride, salmeterol, chelerythrine chloride, paroxetine, trifluoperazine, fluoxetine, methiothepin, nortriptyline, A-77636, rapamycin, SCH-202676 hydrobromide, danusertib (PHA-739358), AZ-960, nicardipine, SB-590885, Thimerosal, ionomycin, U-73343, PAF C16, BX912, and Chlorambucil for the treatment of lymphangioleiomyomatosis (LAM). 
     
     
         7 . A composition comprising at least one a cyclooxygenase (COX) inhibitor and/or an inhibitor of the prostaglandin biosynthetic pathway and at least one compounds selected from the group consisting of nateglinide, Z-L-Phe chloromethyl ketone, clemastine fumarate, supercinnamaldehyde, practolol, fluvastatin Na, sulindac, BIO, amorolfine, spectinomycin, sibutramine HCl, nelfinavir mesylate, moroxydine HCl, nicotine ditartrate, trequinsin, meglumine, tizanidine HCl, CGP-74514A hydrochloride, tioconazole, afatinib, kasugamycin, flupentixol, fluphenazine, mephenytoin, aminoglutethimide, betaxolol hydrochloride, salmeterol, chelerythrine chloride, paroxetine, trifluoperazine, fluoxetine, methiothepin, nortriptyline, A-77636, rapamycin, SCH-202676 hydrobromide, danusertib (PHA-739358), AZ-960, nicardipine, SB-590885, Thimerosal, ionomycin, U-73343, PAF C16, BX912, and Chlorambucil. 
     
     
         8 . The composition of  claim 1 , further comprising at least one pharmaceutically acceptable carrier. 
     
     
         9 .- 59 . (canceled) 
     
     
         60 . The composition of  claim 1 , further comprising rapamycin, and at least one compound selected from the group consisting of SCH-202676 hydrobromide, danusertib (PHA-739358), AZ-960, nicardipine, SB-590885, Thimerosal, ionomycin, U-73343, PAF C16, BX912, and Chlorambucil. 
     
     
         61 . The composition of  claim 6 , further comprising at least one pharmaceutically acceptable carrier. 
     
     
         62 . The composition of  claim 7 , further comprising at least one pharmaceutically acceptable carrier.