Device for determining a condition of an organ and method of operating the same

Abstract

In various embodiments, device for determining a condition of an organ of either a human or an animal may be provided. The device may include a first optical source and a second optical source. The device may also include a detector. The device may additionally include a lens system. The device may further include a switching mechanism configured to switch between an optical examination mode and a Raman mode. The lens system during the optical examination mode may be configured to direct a first light emitted from the first optical source. The lens system during the Raman mode may be configured to direct a second light emitted from the second optical source. The lens systems during the Raman mode may be further configured to direct a third light to the detector.

1 . A device for determining a condition of an organ of either a human or an animal, the device comprising:
 an optical source;   a detector; and   a lens system;   wherein the lens system is configured to direct a light emitted from the optical source; and   wherein the lens system is further configured to direct a further light to the detector.   
     
     
         2 . The device according to  claim 1 , wherein the lens system comprises an objective lens for focusing the light emitted from the optical source. 
     
     
         3 . The device according to  claim 2 , wherein the lens system further comprises an actuator for controlling a position of the objective lens. 
     
     
         4 . The device according to  claim 3 , wherein the actuator is a piezoelectric transducer. 
     
     
         5 . The device according to  claim 3 , wherein the lens system includes an actuator feedback circuit coupling the detector to the actuator. 
     
     
         6 . The device according to  claim 5 , wherein the actuator feedback circuit is configured to receive an output from the detector and further configured to provide a feedback to the actuator based on the output from the detector. 
     
     
         7 . The device according to  claim 6 , wherein the actuator feedback circuit may be configured to determine a focus index based on the output from the detector and further configured to provide a feedback based on the determined focus index and a reference focus index. 
     
     
         8 . The device according to any of  claims 1 , further comprising:
 a dynamic optical element for modulating the light emitted from the optical source.   
     
     
         9 . The device according to  claim 8 , wherein the lens system further comprises a dynamic optical element feedback circuit coupling the detector to the dynamic optical element. 
     
     
         10 . The device according to  claim 9 , wherein the dynamic optical element feedback circuit is configured to generate a skeletonized line based on a line formed by the light. 
     
     
         11 . The device according to  claim 10 , wherein the dynamic optical element is configured to be adjusted based on a feedback from the dynamic optical element feedback circuit until a focus index of each pixel along a subsequent skeletonized line generated reaches a maximum value. 
     
     
         12 . The device according to  claim 8 , wherein the dynamic optical element is a spatial light modulator or a digital micromirror device. 
     
     
         13 . The device according to  claim 1 , wherein the lens system comprises a single beam splitter configured to direct the light. 
     
     
         14 . The device according to  claim 1 , further comprising:
 a processor coupled to the detector.   
     
     
         15 . The device according to  claim 14 , further comprising:
 one or more filters configured to generate one or more narrow-band Raman images from an image captured by the detector;   wherein the processor is configured to generate one or more reconstructed Raman images based on the one or more narrow Raman images, each of the one or more reconstructed Raman images corresponding to one wavelength; and   wherein the processor is further configured to generate a Raman spectrum at each pixel based on the one or more reconstructed Raman images.   
     
     
         16 . The device according to  claim 15 , wherein the one or more filters is configured to generate one or more reference narrow-band Raman images from one or more reference images that contain full spectral information at each pixel for all pixels; and wherein the processor is configured to determine a Wiener matrix based on the one or more reference narrow-band Raman images and the one or more reference images. 
     
     
         17 . The device according to  claim 16 , wherein the one or more reference images is generated based on one or more reference samples, each reference sample including one or more basic biochemical components. 
     
     
         18 . The device according to  claim 16 , wherein the processor is configured to generate the one or more reconstructed Raman images based on the one or more narrow-band Raman images and the Wiener matrix. 
     
     
         19 . The device according to  claim 18 , wherein the processor may be configured to remove fluorescence background from the one or more reconstructed Raman images. 
     
     
         20 . The device according to  15 , wherein the one or more narrow-band Raman images may have a spectral resolution lower than the one or more reconstructed Raman images. 
     
     
         21 . The device according to  15 , wherein the one or more filters may be generated from one or more principal components based on Raman spectra of the reference samples. 
     
     
         22 . The device according to  1 , further comprising:
 an interface portion.   
     
     
         23 . The device according to  claim 22 , wherein the lens system is configured to direct the light emitted from the optical source to the interface portion. 
     
     
         24 . The device according to  claim 23 , wherein the lens system is configured to direct the light from the interface portion to the detector. 
     
     
         25 . The device according to  claim 1 , wherein the further light has a frequency shift from the light emitted from the optical source. 
     
     
         26 . The device according to  claim 1 , wherein the optical source is a laser source.