Composition for prevention, amelioration or treatment of metabolic syndrome

Abstract

A composition comprising (a) and (b), and a food or drink or a medicine comprising the composition, wherein (a) is at least a kind of polyphenols selected from the group consisting of a polyphenol containing 15 mass % or more of proanthocyanidin having a polymerization degree of 1 to 3, hesperidin, a hesperidin derivative, and hesperetin; and (b) is at least a kind of xanthine derivatives, the mass ratio of (a):(b) in the composition being 1:(0.001 to 5), are useful for the prevention, amelioration, or treatment of metabolic syndrome, disorders of lipid metabolism (for example, fatty liver, hyperlipidemia), obesity (for example, visceral fat accumulation, subcutaneous fat accumulation), or the like.

1 . A method for the amelioration, or treatment of metabolic syndrome in a subject suffering therefrom comprising administering to said subject the composition comprising (a) and (b):
 (a) at least a kind of polyphenols selected from the group consisting of hesperidin, and glucosyl hesperetin; and   (b) caffeine, the mass ratio of (a):(b) in the composition being 1:(more than 0.1 to not more than 0.86).   
     
     
         2 . The method according to  claim 1 , wherein the mass ratio of (a):(b) in the composition is 1:(more than 0.1 to not more than 0.16). 
     
     
         3 . (canceled) 
     
     
         4 . A method for the amelioration or treatment of metabolic syndrome, comprising administering medicine, a food or drink, or a feed comprising the composition according to  claim 1 . 
     
     
         5 . (canceled) 
     
     
         6 . A method for the amelioration or treatment of metabolic syndrome, comprising administering a medicine, a food or drink, or a feed comprising the composition defined in  claim 2 .