Combination vaccines with lower doses of antigen and/or adjuvant

Abstract

Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.

1 . An immunogenic composition comprising (i) an oil-in-water emulsion adjuvant (ii) a diphtheria toxoid, a tetanus toxoid, a pertussis toxoid, and a Hib conjugate (iii) a hepatitis B virus surface antigen and/or an inactivated poliovirus antigen. 
     
     
         2 . The composition of  claim 1 , wherein the composition is aluminium-free. 
     
     
         3 . The composition of  claim 1 , wherein the oil-in-water emulsion adjuvant has oil droplets with a sub-micron diameter. 
     
     
         4 . The composition of  claim 1 , wherein the oil-in-water emulsion adjuvant includes squalene and/or polysorbate 80. 
     
     
         5 . The composition of  claim 1 , further comprising conjugated capsular saccharide from one or more of meningococcal serogroups A, C, W135 and/or Y. 
     
     
         6 . The composition of  claim 1 , further comprising conjugated capsular saccharide from one or more of pneumococcal serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F and/or 33F. 
     
     
         7 . The composition of  claim 1 , further comprising (i) a meningococcal factor H binding protein antigen and/or (ii) a Neisserial Heparin Binding Antigen and/or (iii) a meningococcal NhhA antigen and/or (iv) a meningococcal outer membrane vesicle.