Magnesium-containing products and uses thereof

Abstract

A composition including a hydrate form of magnesium oxide, denoted as MgO.(H2O)n, at a concentration ranging from 1 to 100 weight percent (wt %), where n is any value from 0.1 to 2. The composition may further include MgO at a concentration ranging from 0 to 99 wt %; or Mg(OH)2, at a concentration ranging from 0 to 99 wt %; or Mg(OH)2 at a concentration ranging from 0 to 99 wt %, and MgO, at a concentration ranging from 0 to 99 wt %.

What is claimed is: 
     
         1 . A method of treating leg cramps in a subject in need thereof and/or supplementing magnesium in a subject undergoing extensive exercise, the method comprising orally administering to the subject a therapeutically effective amount of a composition comprising a hydrate form of magnesium oxide, denoted as MgO.(H 2 O)n, at a concentration in a range of from 1 to 100 weight percent (wt %), where n is any value from 0.1 to 2, wherein an amount of elemental magnesium in said therapeutically effective amount is in a range of from 100 mg to 520 mg. 
     
     
         2 . The method of  claim 1 , wherein orally administering the composition is effected daily. 
     
     
         3 . The method of  claim 2 , wherein orally administering the composition is effected before bed time. 
     
     
         4 . The method of  claim 1 , wherein an amount of elemental magnesium in said therapeutically effective amount is in a range of from 200 mg to 520 mg. 
     
     
         5 . The method of  claim 1 , wherein an amount of elemental magnesium in said therapeutically effective amount is in a range of from 360 mg to 440 mg. 
     
     
         6 . The method of  claim 1 , wherein said composition comprises:
 Magnesium oxide hydrate MgO.(H 2 O)n, at a concentration in a range of from 1 to 100 wt %, wherein n in any value from 0.1 to 2, and MgO at a concentration in a range of from 0 to 99 wt %; or   Magnesium oxide hydrate MgO.(H 2 O)n, at a concentration in a range of from 1 to 100 wt %, wherein n in any value from 0.1 to 2, and Mg(OH) 2 , at a concentration in a range of from 0 to 99 wt %; or   Magnesium oxide hydrate MgO.(H 2 O)n, at a concentration in a range of from 1 to 100 wt %, wherein n is any value from 0.1 to 2, Mg(OH) 2  at a concentration in a range of from 0 to 99 wt %, and MgO at a concentration in a range of from 0 to 99 wt %.   
     
     
         7 . The method of  claim 1 , wherein n is in a range of from 0.3 to 1. 
     
     
         8 . The method of  claim 1 , wherein a concentration of said MgO.(H 2 O)n in said composition is selected from the group including: at least 10 wt %, at least 20 wt %, at least 30 wt %, at least 40 wt %, at least 50 wt %, at least 60 wt %, at least 70 wt % or at least 80 wt % of a total weight of the composition. 
     
     
         9 . The method of  claim 1 , wherein said composition is in a form of a plurality of particles. 
     
     
         10 . The method of  claim 1 , wherein said composition further comprises an excipient selected from the group consisting of starch and cellulose derivatives. 
     
     
         11 . The method of  claim 1 , wherein said composition further comprises at least one additional agent selected from the group consisting of Vitamin D, Vitamin B 6 , and Vitamin E. 
     
     
         12 . The method of  claim 1 , wherein said composition is formulated as a unit dosage form for oral administration, wherein an amount of elemental magnesium in said unit dosage form is in a range of from 100 mg to 520 mg. 
     
     
         13 . The method of  claim 12 , wherein an amount of elemental magnesium in said unit dosage form is in a range of from 200 mg to 520 mg. 
     
     
         14 . The method of  claim 12 , wherein an amount of elemental magnesium in said unit dosage form is in a range of from 360 mg to 440 mg. 
     
     
         15 . The method of  claim 12 , wherein said unit dosage form is a capsule. 
     
     
         16 . The method of  claim 12 , wherein said unit dosage form is identified for use such that a daily dose consists of one unit of said unit dosage form. 
     
     
         17 . The method of  claim 12 , wherein said unit dosage form is identified for use before bed time. 
     
     
         18 . The method of  claim 1 , being for treating leg cramps in said subject in need thereof. 
     
     
         19 . The method of  claim 1 , being for supplementing magnesium in said subject undergoing extensive exercise. 
     
     
         20 . The method of  claim 1 , wherein said extensive exercise is sport exercise.