Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1

Abstract

The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.

1 - 29 . (canceled) 
     
     
         30 . A method of treating a patient in need of treatment for pain or inflammation associated with arthritis or osteoarthritis said method comprising administering to the patient an effective amount of 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, in combination with an effective amount of a second agent selected from the group consisting of ibuprofen, aspirin, acetaminophen, celecoxib, naproxen, and ketoprofen.