Antifungal and antiparasitic polyene macrolides

Abstract

In certain aspects, the present disclosure provides for novel, water-soluble polyene macrolides and salts or solvates thereof and methods of making the water-soluble polyene macrolides. Also provided are compositions and methods for inhibiting, preventing, and/or treating fungal and parasitic diseases in a subject.

1 . A compound of Structure (I): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable isomer thereof, wherein:
 R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  are each independently hydrogen, —OH, —SH, amino, nitro, cyano, halo, optionally substituted C 1 -C 6  alkoxy, optionally substituted C 1 -C 6  alkanoyl, amide, carboxy, or ester; and 
 X is a pharmaceutically acceptable cation, wherein the cation is an organic cation or is a cation of aluminum, calcium, lithium, magnesium, or zinc. 
 
     
     
         2 - 94 . (canceled)