US2018237839A1PendingUtilityA1
Selective oxidation of 5-methylcytosine by tet-family proteins
Est. expirySep 26, 2028(~2.2 yrs left)· nominal 20-yr term from priority
G01N 2500/00C12Q 1/6869G01N 33/5308C12Q 2522/10C12Q 1/6806C12Q 1/6827C12Q 1/26G01N 33/5011C12Q 2600/154C12N 9/0071C12Q 2521/531C12Q 2537/164C12N 2501/71C12N 2501/70C12N 2501/724C12N 9/1007
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Claims
Abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
Claims
exact text as granted — not AI-modifiedWe claim:
1 . A kit comprising purified β-glucosyltransferase in a container and a labeled uridine diphosphoglucose in a container.
2 . The kit of claim 1 , further comprising a buffer.
3 . The kit of claim 1 , wherein the labeled uridine diphosphoglucose comprises a radiolabel.
4 . The kit of claim 3 , wherein the radiolabel comprises 14 C or 3 H.Join the waitlist — get patent alerts
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