Compositions and uses thereof for controlling ectoparasites in non-human mammals

Abstract

The invention relates to novel veterinary compositions comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound. The invention also relates to the use of such compositions for controlling ectoparasites in a non-human mammal.

1 . A veterinary composition comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound. 
     
     
         2 . The veterinary composition according to  claim 1 , wherein the neonicotinoid compound is dinotefuran, derivatives, metabolites or salts thereof. 
     
     
         3 . The veterinary composition according to  claim 1 , wherein the N-arylpyrazole compound is fipronil, derivatives, metabolites or salts thereof. 
     
     
         4 . The veterinary composition according to  claim 1 , wherein the ratio of the neonicotinoid compound to the N-arylpyrazole compound is from about 6:1 to about 1:6, preferably from about 2:1 to about 1:3. 
     
     
         5 . The veterinary composition according to  claim 1 , wherein the ratio of the neonicotinoid compound to the N-arylpyrazole compound is about 1:1.5. 
     
     
         6 . A method for controlling ectoparasites in a non-human mammal comprising administering to said non-human mammal a veterinary composition comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound. 
     
     
         7 . The method according to  claim 6 , wherein the ectoparasites are fleas and/or ticks. 
     
     
         8 . The method according to  claim 6 , wherein the non-human mammal is a dog or a cat. 
     
     
         9 . The method according to  claim 6 , wherein the composition is administered by topical application. 
     
     
         10 . The method according to  claim 6 , wherein the composition is a spot-on, a pour-on or a line-on composition. 
     
     
         11 . A method for treating ectoparasites infestations in a non-human mammal comprising administering to said non-human mammal a veterinary composition comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound. 
     
     
         12 . A kit comprising (a) one compartment comprising a neonicotinoid compound, preferably dinotefuran, derivatives, metabolites or salts thereof and (b) a second compartment comprising a N-arylpyrazole compound, preferably fipronil, derivatives, metabolites or salts thereof, as a combined preparation for simultaneous, separate or sequential use, in particular for controlling ectoparasites in a non-human mammal. 
     
     
         13 . The kit according to  claim 12 , wherein the amounts of the neonicotinoid compound in (a) and N-arylpyrazole in (b) are such that the ratio of the neonicotinoid compound to the N-arylpyrazole compound is from about 6:1 to about 1:6, preferably from about 2:1 to about 1:3, more preferably about 1:1.5. 
     
     
         14 . The kit according to  claim 12 , wherein it further comprises a package leaflet or user instruction including the information that said preparation is to be used for controlling ectoparasites, preferably fleas and/or ticks in a non-human mammal, preferably in a dog or a cat.