Disinfectant Composition with Rapid Antiviral Efficacy

Abstract

A disinfectant composition that contains a unique combination of a primary antiviral agent and a secondary antiviral agent is provided. More particularly, the primary antiviral agent includes a polyprotic acid having a low first acid dissociation constant and the secondary antiviral agent is selected from the group consisting of an anionic N-acyl compound, metal halide salt, amine compound, amine compound, aliphatic amine oxide, alkyl glycoside, alcohol ethoxylate, and combinations thereof. By selectively controlling the particular nature of each antiviral agent and their relative concentration, the present inventors have discovered that a synergistic affect can be achieved in which the disinfectant composition is capable of exhibiting an antiviral efficacy against non-enveloped viruses.

1 . A disinfectant composition comprising:
 from about 0.1 wt. % to about 10 wt. % of a primary antiviral agent, wherein the primary antiviral agent includes a polyprotic acid having a first acid dissociation constant of about 3.0 or less;   from about 0.1 wt. % to about 15 wt. % of a secondary antiviral agent, wherein the secondary antiviral agent is selected from the group consisting of anionic N-acyl compounds, metal halide salts, amine compounds, aliphatic amine oxides, alkyl glycosides, alcohol ethoxylates, and combinations thereof; and   from about 70 wt. % to about 99.5 wt. % of a solvent system that includes one or more solvents, wherein water constitutes at least about 50 wt. % of the solvent system;   wherein the composition has a pH of about 4.5 or less, and further wherein the composition exhibits a reduction in virus infectivity of about 30% or more after being exposed to a non-enveloped virus for 10 minutes.   
     
     
         2 . The disinfectant composition of  claim 1 , wherein the polyprotic acid is maleic acid. 
     
     
         3 . The disinfectant composition of  claim 2 , wherein the secondary antiviral agent is selected from the group consisting of anionic N-acyl compounds, metal halide salts, alcohol ethoxylates, aliphatic amine oxides, alkyl glycosides, and combinations thereof. 
     
     
         4 . The disinfectant composition of  claim 1 , wherein the polyprotic acid is sulfosuccinic acid. 
     
     
         5 . The disinfectant composition of  claim 4 , wherein the secondary antiviral agent is selected from the group consisting of anionic N-acyl compounds, metal halide salts, and combinations thereof. 
     
     
         6 . The disinfectant composition of  claim 1 , wherein the polyprotic acid is phosphoric acid. 
     
     
         7 . The disinfectant composition of  claim 6 , wherein the secondary antiviral agent is selected from the group consisting of anionic N-acyl compounds, metal halide salts, amine compounds, and combinations thereof. 
     
     
         8 . The disinfectant composition of  claim 1 , wherein the anionic N-acyl compounds have the following general structure: 
       
         
           
           
               
               
           
         
       
       wherein,
 R 1  is a C 4  to C 30  fatty acid chain; 
 R 2  is an alkylene, which may optionally be substituted with alkyl, alkoxyl, alkenyl, aryl, aralkyl, alkaryl, or heterocyclyl, and which may optionally be interrupted at one or more positions by an oxygen atom; 
 X is O or NR 3 , 
 R 3  is H or a C 1  to C 8  alkyl; 
 Y is SO 3  or CO 2 , and 
 M is a cation. 
 
     
     
         9 . The disinfectant composition of  claim 8 , wherein Y is SO 3 . 
     
     
         10 . The disinfectant composition of  claim 9 , wherein the anionic N-acyl compounds include an N-acyl taurate having the following general structure: 
       
         
           
           
               
               
           
         
       
       wherein,
 R 7  is a C 8  to C 30  fatty acid chain; 
 R 8  is H or a C 1  to C 8  alkyl; 
 R 9  and R 10  are each independently H or a C 1  to C 8  alkyl; and 
 M +  is a cation. 
 
     
     
         11 . The disinfectant composition of  claim 10 , wherein the N-acyl taurate is sodium methyl lauroyl taurate, sodium methyl myristoyl taurate, potassium methyl myristoyl taurate, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, calcium methyl oleoyl taurate, potassium methyl oleoyl taurate, ammonium methyl oleoyl taurate, or a combination thereof. 
     
     
         12 . The disinfectant composition of  claim 1 , wherein the metal halide salts contain a metal cation having an oxidation state of +2 or greater. 
     
     
         13 . The disinfectant composition of  claim 12 , wherein the metal halide salts includes iron(II) chloride, iron(III) chloride, zinc chloride, copper(II) chloride, aluminum(III) chloride, aluminum chlorohydrate having the formula, Al n Cl (3n-m) (OH) m  wherein n and m are independently from 1 to 5, or a combination thereof. 
     
     
         14 . The disinfectant composition of  claim 1 , wherein the amine compounds have the following general structure: 
       
         
           
           
               
               
           
         
       
       wherein,
 Z is O, NH, or NH 2   + Q − , wherein Q is an anion; and 
 R 10 , R 11 , R 12 , and R 13  are independently hydrogen, hydroxyl, carboxyl, alkyl, carboxyalkyl, or NR 14 R 15 , wherein R 14  and R 15  are independently H or alkyl. 
 
     
     
         15 . The disinfectant composition of  claim 14 , wherein Z is O. 
     
     
         16 . The disinfectant composition of  claim 15 , wherein the amine compounds include urea or a derivative thereof. 
     
     
         17 . The disinfectant composition of  claim 14 , wherein Z is NH 2   + . 
     
     
         18 . The disinfectant composition of  claim 15 , wherein the amine compounds include guanidine hydrochloride, aminoguanidine hydrochloride, or a combination thereof. 
     
     
         19 . The disinfectant composition of  claim 1 , wherein the aliphatic amine oxides have the following general structure: 
       
         
           
           
               
               
           
         
       
       wherein,
 R is an alkyl, alkenyl, or alkylamido group having from 8 to 28 carbon atoms; and 
 R′ are each independently hydrogen or a C 1 -C 4  alkyl group. 
 
     
     
         20 . The disinfectant composition of  claim 19 , wherein the aliphatic amine oxides include decylamine oxide, behenamine oxide, lauramine oxide, lauramidopropylamine oxide, palmitamidopropylamine oxide, isostearamidopropylamine oxide, or a combination thereof. 
     
     
         21 . The disinfectant composition of  claim 1 , wherein the alkyl glycosides includes alkyl groups having 4 to 12 carbon atoms. 
     
     
         22 . The disinfectant composition of  claim 21 , wherein the alkyl glycosides include decyl glucoside, octyl glucoside, lauryl glucoside, or a combination thereof. 
     
     
         23 . The disinfectant composition of  claim 1 , wherein the alcohol ethoxylates include C 11-15  pareth-3, C 11-15  pareth-12, laureth-9, PEG-100 hydrogenated castor oil, or a combination thereof. 
     
     
         24 . The disinfectant composition of  claim 1 , further comprising a cationic surfactant. 
     
     
         25 . The disinfectant composition of  claim 1 , wherein the non-enveloped virus includes rhinovirus, poliovirus, adenovirus, norovirus, papillomavirus, feline calicivirus, coxsackievirus, enterovirus, hepatitis A virus, parvovirus, rotavirus, or a combination thereof. 
     
     
         26 . The disinfectant composition of  claim 1 , wherein the composition exhibits a reduction in virus infectivity of about 30% or more after being exposed to Phi X174 (ATCC 13706-B1) for 10 minutes. 
     
     
         27 . The disinfectant composition of  claim 1 , wherein the composition exhibits a reduction in virus infectivity of about 70% or more after being exposed to Phi X174 (ATCC 13706-B1) for 10 minutes. 
     
     
         28 . Use of the disinfectant composition of  claim 1  against a non-enveloped virus selected from the families Picornaviridae, Reoviridae, Caliciviridae, Papovaviridae, Adenoviridae, Parvoviridae, and combinations thereof. 
     
     
         29 . A method for disinfecting a surface, the method comprising contacting the surface with the disinfectant composition of  claim 1 . 
     
     
         30 . The method of  claim 29 , wherein the surface is a hard surface. 
     
     
         31 . The method of  claim 29 , wherein the disinfectant composition is disposed on a wipe prior to being applied to the surface.