US2018194747A1PendingUtilityA1

Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof

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Assignee: BOEHRINGER INGELHEIM INTPriority: Nov 2, 2011Filed: Dec 13, 2017Published: Jul 12, 2018
Est. expiryNov 2, 2031(~5.3 yrs left)· nominal 20-yr term from priority
Inventors:Armin HeckelSara FrattiniDieter HamprechtJoerg Kley
A61P 5/00A61P 43/00A61P 37/08A61P 31/10A61P 31/12A61P 31/04A61P 33/10A61P 27/16A61P 1/18A61P 11/14A61P 11/02A61P 11/06A61P 11/00C07D 401/12C07D 401/14
59
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Claims

Abstract

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

Claims

exact text as granted — not AI-modified
1 . A method for the treatment of cystic fibrosis comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable acid addition salt of any one of the above compounds. 
     
     
         2 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         3 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         4 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         5 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         6 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         7 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         8 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         9 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         10 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         11 . The method according to  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         12 . A method for the treatment of chronic obstructive pulmonary disease (COPD) comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable acid addition salt of any one of the above compounds. 
     
     
         13 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         14 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         15 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         16 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         17 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         18 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         19 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         20 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         21 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof. 
     
     
         22 . The method according to  claim 12 , wherein the compound is 
       
         
           
           
               
               
           
         
       
       or a pharmacologically acceptable salt thereof.

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