Dermatological compositions and methods

Abstract

Dermatological compositions (methods of making and using) that include one or more anesthetic agents and/or one or more anti-inflammatory agents and/or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.

What is claimed is: 
     
         1 . A dermatological composition comprising:
 about 8 weight percent to about 40 weight percent of deodorized ammonium lactate;   about 1 weight percent to about 20 weight percent of mineral oil;   about 0.5 weight percent to about 3 weight percent of dimethylsiloxane polymers,   a nonionic surfactant;   a preservative;   about 1 weight percent to about 10 weight percent of glycerin;   about 0.0001 weight percent to about 10 weight percent of xanthan gum;   stearyl alcohol;   about 30% and typically no greater than about 60% by weight of water;   wherein the composition has a pH of about 4.5 to about 5.5.   
     
     
         2 . The dermatological composition of  claim 1  wherein:
 the deodorized ammonium lactate is present in the composition in an amount of about 19.7 weight percent; 
 the mineral oil is present in the composition in an amount of about 10 weight percent; 
 the dimethylsiloxane polymers are present in the composition in an amount of about 2 weight percent; 
 the glycerin is present in the composition in an amount of about 4 weight percent; 
 the xanthan gum is present in the composition in an amount of about 0.2 weight percent; and 
 the nonionic surfactant comprises glyceryl stearate. 
 
     
     
         3 . A dermatological composition comprising:
 about 10 weight percent to about 15 weight percent of ammonium lactate;   about 3 weight percent to about 7 weight percent of sodium lactate;   about 3 weight percent to about 7 weight percent of potassium lactate;   about 1 weight percent to about 20 weight percent of mineral oil;   about 0.5 weight percent to about 3 weight percent of dimethylsiloxane polymers,   a nonionic surfactant;   a preservative;   petrolatum;   about 1 weight percent to about 10 weight percent of glycerin;   about 0.0001 weight percent to about 10 weight percent of xanthan gum;   stearyl alcohol;   about 30% and typically no greater than about 60% by weight of water;   wherein the composition has a pH of about 4.5 to about 5.5.   
     
     
         4 . The dermatological composition of  claim 3  wherein:
 the ammonium lactate is present in the composition in an amount of about 10.5 weight percent; 
 the sodium lactate is present in the composition in an amount of about 4.2 weight percent; 
 the potassium lactate is present in the composition in an amount of about 4.2 weight percent; 
 the mineral oil is present in the composition in an amount of about 4 weight percent; 
 the dimethylsiloxane polymers are present in the composition in an amount of about 2 weight percent; 
 the glycerin is present in the composition in an amount of about 5 weight percent; 
 the xanthan gum is present in the composition in an amount of about 0.3 weight percent; and 
 the nonionic surfactant comprises glyceryl stearate. 
 
     
     
         5 . A method of treating skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition of  claim 1 . 
     
     
         6 . A method of treating skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition of  claim 2 . 
     
     
         7 . A method of treating skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition of  claim 3 . 
     
     
         8 . A method of treating skin of a subject, the method comprising contacting the subject's skin with a dermatologic composition of  claim 4 .