Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors

Abstract

Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.

1 - 14 . (canceled) 
     
     
         15 . A method for treating sarcoma in a subject comprising administering to the subject a therapeutically effective amount of a compound having the structure: 
       
         
           
           
               
               
           
         
       
     
     
         16 . The method of  claim 15 , wherein the sarcoma is selected from the group consisting of a sarcoma of the bone, a sarcoma of the cartilage, a sarcoma of the fat, a sarcoma of the muscle, a sarcoma of the blood vessels, a sarcoma of the connective tissue and a sarcoma of the supportive tissue. 
     
     
         17 . The method of  claim 15 , wherein the sarcoma is selected from the group consisting of: chondrosarcoma, Ewing's sarcoma, malignant hemangioendothelioma, malignant schwannoma, osteosarcoma, soft tissue sarcomas, alveolar soft part sarcoma, angiosarcoma, cystosarcoma phylloides, dermatofibrosarcoma, desmoid tumor, epithelioid sarcoma, extraskeletal osteosarcoma, fibrosarcoma, hemangiopericytoma, hemangiosarcoma, Kaposi's sarcoma, leiomyosarcoma, liposarcoma, lymphangiosarcoma, lymphosarcoma, malignant fibrous histiocytoma, neurofibrosarcoma, rhabdomyosarcoma, and synovial sarcoma. 
     
     
         18 . The method of  claim 15 , wherein survival of the subject is prolonged. 
     
     
         19 . The method of  claim 15 , wherein the method further comprises administering an additional cancer agent. 
     
     
         20 . The method of  claim 19 , wherein the additional cancer agent is ifosfamide or doxorubicin.