Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications

Abstract

Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.

1 . A topical composition comprising: a polysaccharide gel matrix; and a substance, alone, or in combination with, an effective amount of a therapeutic agent deliverable to a skin surface, wherein the therapeutic agent is a salt, a solvate, a prodrug, or a derivative of the therapeutic agent, and wherein the substance, alone or in combination, is entrapped within the matrix. 
     
     
         2 . A composition according to  claim 1 , wherein the polysaccharide is a cross-linked polymer of hyaluronic acid, a salt or a derivative of the polymer. 
     
     
         3 . A composition according to  claim 2 , wherein the polymer is in an equilibrium form and is hylan B. 
     
     
         4 . A topical composition according to  claim 2 , wherein the polymer is in a non-equilibrium form and is hylan B. 
     
     
         5 . A composition according to  claim 1 , wherein the substance is a hydrophilic organic ingredient. 
     
     
         6 . A composition according to  claim 5 , wherein the hydrophilic organic ingredient is an α-, β-, γ- or δ-hydroxy acid, an α-amino acid, a β-amino acid, a γ-amino acid, a δ-amino acid, a glycerin, a vitamin, a vitamin derivative, a sugar, an essential oil, a water-soluble oil, a fragrance, a natural polymer, a synthetic polymer, a cross-linked natural polymer, a cross linked synthetic polymer, a peptide, a protein, a polysaccharide or a nucleic acid. 
     
     
         7 . A composition according to  claim 6  wherein the hydrophilic organic ingredient is an α-hydroxy acid, namely, lactic acid. 
     
     
         8 . A composition according to  claim 1 , wherein the substance is a hydrophobic organic ingredient. 
     
     
         9 . A composition according to  claim 8 , wherein the hydrophobic organic ingredient is a petrolatum, a fatty acid, a fatty alcohol, an oil, a lipid or a silicone. 
     
     
         10 . A composition according to  claim 1 , wherein the substance is an inorganic ingredient. 
     
     
         11 . A composition according to  claim 10 , wherein the inorganic ingredient is titanium dioxide, silica, calcium chloride, kaolin, talc or tantalum. 
     
     
         12 . A composition according to  claim 1 , wherein the therapeutic agent is an anti-inflammatory agent, an antiseptic agent, an anti-infective agent, a mucous membrane agent, a cleansing agent, a preservative, an astringent, an antihistamine, an analgesic, an anesthetic, an acne medication, an antifungal agent, an anti-pruritic agent, a hormone, a growth factor, a moisturizing agent, a sunscreen, a hyperpigmentation agent, an antioxidant or a nutritional agent. 
     
     
         13 . A composition according to  claim 12 , wherein the nutritional agent is a vitamin. 
     
     
         14 . A composition according to  claim 12 , wherein the sunscreen is Parsol MCX. 
     
     
         15 . A composition according to  claim 12 , wherein the therapeutic agent is an anti-inflammatory agent in combination with an anti-infective agent. 
     
     
         16 . A composition according to  claim 15 , wherein the anti-inflammatory agent is a steroid agent. 
     
     
         17 . A composition according to  claim 16 , wherein the steroid agent is hydrocortisone, hydrocortisone acetate or prednisone. 
     
     
         18 . A composition according to  claim 15 , wherein the anti-infective agent is an antibiotic. 
     
     
         19 . A composition according to  claim 18 , wherein the antibiotic is bacitracin. 
     
     
         20 . A composition according to  claim 12 , wherein the antiseptic agent is povidone iodine.