US2018179587A1PendingUtilityA1
Selective oxidation of 5-methylcytosine by tet-family proteins
Est. expirySep 26, 2028(~2.2 yrs left)· nominal 20-yr term from priority
C12Q 1/6827C12Q 2537/164C12Q 1/26G01N 2500/00C12Q 2521/531C12Q 2600/154G01N 33/5308C12N 9/0071C12Q 1/6869C12Q 2522/10C12N 2501/71C12Q 1/6806G01N 33/5011C12N 2501/70C12N 2501/724C12N 9/1007
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Claims
Abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
Claims
exact text as granted — not AI-modified1 - 96 . (canceled)
97 . A kit comprising a β-glucosyltransferase with glycerol in a container and a uridine diphosphoglucose with an added element in a container.
98 . The kit of claim 97 , further comprising a buffer.
99 . The kit of claim 97 , wherein the added element is a radiolabel.
100 . The kit of claim 99 , wherein the radiolabel comprises 14 C or 3 H.Join the waitlist — get patent alerts
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