US2018177900A1PendingUtilityA1

Radiolabelling Process

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Assignee: GE HEALTHCARE LTDPriority: Mar 28, 2013Filed: Feb 20, 2018Published: Jun 28, 2018
Est. expiryMar 28, 2033(~6.7 yrs left)· nominal 20-yr term from priority
Inventors:Torild Wickstrom
C07C 61/15A61K 51/0402A61K 51/0406C07C 51/377C07B 59/001C07B 2200/05C07C 227/20A61K 51/0497C07C 2601/04C07C 269/06A61K 51/04A61K 51/00Y02P20/55
56
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Claims

Abstract

The present invention relates to a novel composition comprising 1-amino-3-[ 18 F]-fluorocyclobutanecarboxylic acid ([ 18 F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [ 18 F]-FACBC. Also provided by the invention is a method to obtain said composition.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition comprising 1-amino-3-[ 18 F] fluorocyclobutanecarboxylic acid ([ 18 F]-FACBC) and no greater than 50 μg/mL acetonitrile (MeCN). 
     
     
         2 . The composition of  claim 1 , wherein said concentration of MeCN is no greater than 20 μg/mL. 
     
     
         3 . The composition of  claim 1 , having a radioactive concentration (RAC) of between 500-5000 MBq/mL. 
     
     
         4 . The composition of  claim 1 , having a RAC between 1000-5000 MBq/mL. 
     
     
         5 . The composition of  claim 1 , having a radiochemical purity of at least 99%. 
     
     
         6 . A composition comprising trans-1-amino-3-[ 18 F]-fluorocyclobutanecarboxylic acid (anti-[ 18 F]-FACBC): 
       
         
           
           
               
               
           
         
         and no greater than 50 μg/mL acetonitrile (MeCN). 
       
     
     
         7 . The composition of  claim 6 , wherein said concentration of MeCN is no greater than 20 μg/mL. 
     
     
         8 . The composition of  claim 6 , having a radioactive concentration (RAC) of between 500-5000 MBq/mL. 
     
     
         9 . The composition of  claim 6 , having a RAC between 1000-5000 MBq/mL. 
     
     
         10 . The composition of  claim 6 , having a radiochemical purity of at least 99%.

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