Carbohydrate-based peritoneal dialysis fluid comprising glutamine residue

Abstract

The present invention relates to a carbohydrate-based peritoneal dialysis fluid, containing a compound selected from the group consisting of glutamine, preferably L-glutamine; a dipeptide capable of releasing glutamine, L-glutamine in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine, alanyl-glutamine; an oligopeptide consisting of two to seven glutamine, preferably L-glutamine residues; and mixtures thereof. The peritoneal dialysis fluids of the present invention are useful for inhibition of technical failure in a person undergoing peritoneal dialysis treatment.

1 . A glucose-based peritoneal dialysis fluid, containing a compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine and alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues, and   mixtures thereof,   wherein the concentration of said compound in the fluid is 2 mM to 25 mM.   
     
     
         2 . A compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine and alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues and   mixtures thereof,   wherein the concentration of said compound in the fluid is 2 mM to 25 mM, for the specific use of inhibiting technical failure in a peritoneal dialysis treatment with a glucose-based peritoneal dialysis fluid.   
     
     
         3 . A glucose-based peritoneal dialysis fluid comprising a compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine and alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues, and   mixtures thereof,   wherein the concentration of said compound in the fluid is 2 mM to 25 mM, for the specific use of inhibiting technical failure.   
     
     
         4 . The peritoneal dialysis fluid and/or compound according to  claim 1 , characterized in that said oligopeptide is selected from the group consisting of alanyl-glutamine and glutaminyl-alanine. 
     
     
         5 . The peritoneal dialysis fluid and/or compound according to  claim 4  for the specific use of prevention of peritoneal membrane failure, attenuation of barrier dysfunction and prevention of mesothelial cell detachment. 
     
     
         6 . Use of a compound selected from the group consisting of
 L-glutamine,   a dipeptide capable of releasing L-glutamine, in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine, alanyl-glutamine   an oligopeptide consisting of two to seven L-glutamine residues, and   mixtures thereof,   wherein the concentration of said compound in the fluid is 2 mM to 25 mM, for the preparation of a glucose-based peritoneal dialysis fluid for inhibiting technical failure.   
     
     
         7 . Use according to  claim 6  for the prevention of peritoneal membrane failure, attenuation of barrier dysfunction and prevention of mesothelial cell detachment. 
     
     
         8 . The peritoneal dialysis fluid and/or compound according to  claim 2 , characterized in that said oligopeptide is selected from the group consisting of alanyl-glutamine and glutaminyl-alanine. 
     
     
         9 . The peritoneal dialysis fluid and/or compound according to  claim 3 , characterized in that said oligopeptide is selected from the group consisting of alanyl-glutamine and glutaminyl-alanine. 
     
     
         10 . The peritoneal dialysis fluid and/or compound according to  claim 8  for the specific use of prevention of peritoneal membrane failure, attenuation of barrier dysfunction and prevention of mesothelial cell detachment. 
     
     
         11 . The peritoneal dialysis fluid and/or compound according to  claim 9  for the specific use of prevention of peritoneal membrane failure, attenuation of barrier dysfunction and prevention of mesothelial cell detachment.