Coenzyme Q10 Aerosol

Abstract

The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nano dispersion that can be readily aerosolized for inhalation.

What is claimed is: 
     
         1 . An aerosol formulation comprising coenzyme Q10 having an effective particle size of 1 micron or less. 
     
     
         2 . The formulation of  claim 1 , wherein the aerosol is in the form of an emulsion, including a nanoemulsion. 
     
     
         3 . The formulation of  claim 2  further comprising one or more carriers, one or more oils, one or more surfactants or a combination thereof. 
     
     
         4 . A method of making a coenzyme Q10 (CoQ10) composition comprising heating an oil together with CoQ10 so as to form a mixture and then adding one or more surfactants to said mixture. 
     
     
         5 . The method of  claim 4 , wherein water is added to the mixture after the one or more surfactants are added to create an emulsion of containing droplets of CoQ10 and oil. 
     
     
         6 . The method of  claim 5 , wherein the emulsion is dried by freeze drying or spray drying. 
     
     
         7 . The method of  claim 6 , wherein the dried formulation or composition is and subsequently droplets of CoQ10 and oil into a nebulized formulation. 
     
     
         8 . The formulation or composition of  claim 7 , wherein the nebulized formulation contains droplets of CoQ10 and oil that are smaller in size than the droplets of CoQ10 and oil in the emulsion. 
     
     
         9 . A method for making an aerosol formulation containing a desired amount of CoQ10 comprising the steps of:
 dissolving CoQ10 in an oil to create an oil phase;   adding at least one surfactant to said oil phase;   adding water to create an emulsion;   adding at least one tonicity agent to make the emulsion isotonic, said emulsion containing therein droplets of CoQ10 having a first average size;   freeze drying said emulsion; and   dehydrating said freeze dried emulsion with water to make an isotonic emulsion, upon rehydration said emulsion containing therein droplets of CoQ10 having a second average droplet size that is less than said first average droplet size.   
     
     
         10 . The method of  claim 9  having a mixture ratio of 0.03 g of CoQ10 to 0.5 g of oil. 
     
     
         11 . The method of  claim 9  having a mixture ratio of 60 g oil, 1 g water, 0.5 g oil, 0.5 g surfactant, and 0.03 g CoQ10. 
     
     
         12 . The method of  claim 9  wherein said second average droplet size is 117 nanometers or less. 
     
     
         13 . The method of  claim 9  wherein said second average droplet size is 64 nanometers or less. 
     
     
         14 . A method of treating a disorder comprising administering to a subject in need of thereof the aerosol formulation of  claim 9 . 
     
     
         15 . The method of  claim 14 , wherein disorder is cancer, cardiovascular disease or obesity. 
     
     
         16 . The method of  claim 14 , wherein said formulation is administered by aerosolization using a jet, ultrasonic, pressurized or vibrating porous plate nebulizer or other device capable of delivering the formulation to the nasal passages and/or pulmonary airway. 
     
     
         17 . The formulation or composition of claim of  claim 1  wherein said average particle size is 117 nanometers or less. 
     
     
         18 . The formulation or composition of claim of  claim 1  wherein said average particle size is 500 nanometers or less. 
     
     
         19 . The formulation or composition of claim of  claim 1  wherein said average particle size is 200 nanometers or less. 
     
     
         20 . The method of  claim 9  wherein said second average droplet size is 1 micron or less. 
     
     
         21 . An aerosol formulation comprising a therapeutically effective amount of coenzyme Q10. 
     
     
         22 . The formulation of  claim 21 , wherein the aerosol is in the form of an emulsion, including a nanoemulsion. 
     
     
         23 . The formulation of  claim 22  further comprising one or more carriers, one or more oils, one or more surfactants or a combination thereof. 
     
     
         24 . The formulation or composition of claim of  claim 21  wherein said average particle size is 200 nanometers or less.