US2018169187A1PendingUtilityA1

Compositions and methods for the treatment of malnutrition

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Individually held — no corporate assignee on recordPriority: Jun 25, 2015Filed: Jun 24, 2016Published: Jun 21, 2018
Est. expiryJun 25, 2035(~8.9 yrs left)· nominal 20-yr term from priority
Inventors:Gerben Carolus Martinus ZondagReinder Strijker
A23L 33/155A61K 31/198A23L 33/19A23L 33/10A61P 3/02A61K 38/1709A23L 33/175A61K 31/592A23P 10/40A61K 31/56A61K 9/0095A61K 31/593A23V 2002/00A23L 33/105
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Claims

Abstract

The present invention relates to novel liquid or semi-liquid nutritional compositions, and powders to generate such liquid or semi-liquid nutritional compositions, that are beneficial in the treatment of malnutrition and malnutrition-related disorders such as weight loss and muscle wasting. When administered regularly, the nutritional compositions according to the present invention contribute to the reversal of malnutrition and malnutrition-related disorders such as weight loss and/or muscle atrophy.

Claims

exact text as granted — not AI-modified
1 . A liquid or semi-liquid nutritional composition comprising:
 70 to 200 mg/ml dairy proteins;   30 to 60 ng/ml vitamin D or a derivative thereof; and   0.2 to 1 mg/ml ursolic acid;   wherein the casein:whey ratio in said dairy proteins ranges from 20:80 to 80:20 and wherein 30 to 45% of the total amino acid content is a mixture of leucine, isoleucine and valine.   
     
     
         2 . A liquid or semi-liquid nutritional composition according to  claim 1 , wherein the concentration of dairy proteins is from about 75 to about 180 mg/ml, such as from about 80 to about 160 mg/ml, from about 85 to about 140 mg/ml, from about 90 to about 130 mg/ml, from about 95 to about 125 mg/ml, from about 100 to a about 120 mg/ml. 
     
     
         3 . A liquid or semi-liquid nutritional composition according to  claim 1 , wherein the concentration vitamin D or a derivative thereof is from about 32 to about 55 ng/ml, from about 35 to about 45 ng/ml. 
     
     
         4 . A liquid or semi-liquid nutritional composition according to  claim 1 , wherein the concentration of ursolic acid is from about 0.25 to about 0.95 mg/ml, such as from about 0.3 to about 0.9 mg/ml or from about 0.35 to about 0.85 mg/ml. 
     
     
         5 . A liquid or semi-liquid nutritional composition according to  claim 1 , wherein the casein:whey ratio is from about 30:70 to about 70:30, such as from about 40:60 to about 68:32, from about 45:55 to about 65:35. 
     
     
         6 . A liquid or semi-liquid nutritional composition according to  claim 1 , comprising valine and isoleucine in a concentration of 7 to 10% of the total amino acid content and leucine in a concentration of 16 to 25% of the total amino acid content, and wherein valine, isoleucine and leucine are present in free and bound form. 
     
     
         7 . A liquid or semi-liquid nutritional composition according to  claim 1 , comprising from about 1.5 to about 3 Kcal/ml such as from about 1.8 to about 2.7 Kcal/ml or from about 2 to about 2.5 Kcal/ml 
     
     
         8 . A powder formulation comprising
 dairy proteins;   vitamine D or a derivative thereof;   ursolic acid; and   optionally an amino acid premix comprising free leucine, free isoleucine and free valine, in suitable amounts that when it is combined with a suitable carrier provides for a liquid or semi-liquid nutritional composition according to  claim 1 .   
     
     
         9 . A powder formulation according to  claim 8 , wherein the suitable carrier is water. 
     
     
         10 . A powder formulation according to  claim 8 , wherein a suitable amount of carrier is from about 1.5 to about 3 ml per gram of powder formulation, such as from about 1.7 to about 2.8 ml per gram of powder formulation. 
     
     
         11 . A powder formulation comprising
 an amino acid premix comprising free leucine, free isoleucine and free valine;   vitamine D or a derivative thereof; and   ursolic acid;   in suitable amounts that when it is combined with a dairy-protein containing product such as milk or yoghurt, provides for a liquid or semi-liquid nutritional composition according to  claim 1 .   
     
     
         12 . A nutritional composition comprising per 100 Kcal:
 from about 2.5 to about 8.5 grams dairy proteins;   from about 1.2 to about 3.0 μg vitamin D or a derivative thereof; and   from about 8 to about 50 mg ursolic acid;   wherein the casein:whey ratio in said dairy proteins is from 20:80 to 80:20 and wherein 30 to 45% of the total amino acid content is a mixture of leucine, isoleucine and valine.   
     
     
         13 . A nutritional composition according to  claim 12 , wherein the amount of ursolic acid is from about 15 to about 48, such as, from about 20 to about 46, from about 25 to about 44, from about 30 to about 40 or about 35 mg per 100 Kcal of composition. 
     
     
         14 . A nutritional composition according to  claim 12 , wherein the composition is a powder. 
     
     
         15 . A method for treating a patient suffering from malnutrition, weight loss and/or muscle atrophy comprising administering the liquid or semi-liquid nutritional composition according to  claim 1 . 
     
     
         16 . A method for treating a patient suffering from malnutrition, weight loss and/or muscle atrophy comprising administering the powder formulation composition according to  claim 11 . 
     
     
         17 . A method for treating a patient suffering from malnutrition, weight loss and/or muscle atrophy comprising administering the nutritional composition according to  claim 12 .

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