Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof

Abstract

Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.

1 . A nutritional composition comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, and from 40 mg/L to 185 mg/L of total long chain omega-3 fatty acids. 
     
     
         2 . The nutritional composition of  claim 1 , wherein the long chain omega-3 fatty acid comprises docosahexaenoic acid. 
     
     
         3 . The nutritional composition of  claim 2  further comprising from 0.001 μg/mL to 5 μg/mL of a carotenoid. 
     
     
         4 . The nutritional composition of  claim 2 , wherein the composition further includes long chain omega-6 fatty acids and a ratio of long chain omega-6 fatty acids to long chain omega-3 fatty acids is from about 2:1 to about 3:1. 
     
     
         5 . The nutritional composition of  claim 1  further comprising a nucleotide in an amount of from 10 mg/mL to 200 mg/mL. 
     
     
         6 . The nutritional composition of  claim 1 , wherein the nutritional composition is a nutritional powder or ready-to-feed nutritional liquid. 
     
     
         7 . The nutritional composition of  claim 6 , wherein the nutritional composition is a nutritional powder and the powder is a spray dried powder. 
     
     
         8 . The nutritional composition of  claim 6 , wherein the nutritional composition is a ready-to-feed nutritional liquid. 
     
     
         9 . The nutritional composition of  claim 1 , wherein the human milk oligosaccharide is derived from a fermentation process, an enzymatic process, a chemical process, or a combination thereof. 
     
     
         10 . A nutritional composition comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, from 40 mg/L to 185 mg/L of total long chain omega-3 fatty acids, and a source of protein, wherein the source of protein comprises partially hydrolyzed protein. 
     
     
         11 . The nutritional composition of  claim 10 , wherein the long chain omega-3 fatty acid comprises docosahexaenoic acid. 
     
     
         12 . The nutritional composition of  claim 10  further comprising from 0.001 μg/mL to 5 μg/mL of a carotenoid. 
     
     
         13 . The nutritional composition of  claim 10 , wherein the composition further includes long chain omega-6 fatty acids and a ratio of long chain omega-6 fatty acids to long chain omega-3 fatty acids ranges from about 2:1 to about 3:1. 
     
     
         14 . The nutritional composition of  claim 10  further comprising a nucleotide in an amount of from 10 mg/mL to 200 mg/mL. 
     
     
         15 . The nutritional composition of  claim 10 , wherein the nutritional composition is a nutritional powder or ready-to-feed nutritional liquid. 
     
     
         16 . The nutritional composition of  claim 15 , wherein the nutritional composition is a nutritional powder and the powder is a spray dried powder. 
     
     
         17 . The nutritional composition of  claim 15 , wherein the nutritional composition is a ready-to-feed nutritional liquid. 
     
     
         18 . The nutritional composition of  claim 10 , wherein the human milk oligosaccharide is derived from a fermentation process, an enzymatic process, a chemical process, or a combination thereof. 
     
     
         19 . A human milk fortifier comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, and from 0.001 μg/mL to 5 μg/mL of a carotenoid. 
     
     
         20 . The human milk fortifier of  claim 19  further comprising from 40 mg/L to 185 mg/L of total long chain omega-3 fatty acids. 
     
     
         21 . The human milk fortifier of  claim 20 , wherein the long chain omega-3 fatty acid comprises docosahexaenoic acid. 
     
     
         22 . The human milk fortifier of  claim 20 , wherein the composition further includes long chain omega-6 fatty acids and a ratio of long chain omega-6 fatty acids to long chain omega-3 fatty acids ranges from about 2:1 to about 3:1. 
     
     
         23 . The human milk fortifier of  claim 19  further comprising a nucleotide in an amount of from 10 mg/mL to 200 mg/mL. 
     
     
         24 . The human milk fortifier of  claim 19 , wherein the human milk oligosaccharide is derived from a fermentation process, an enzymatic process, a chemical process, or a combination thereof. 
     
     
         25 . The human milk fortifier of  claim 19 , wherein the human milk oligosaccharide is derived from a source selected from human, bovine, ovine, porcine, caprine, or combinations thereof. 
     
     
         26 . The human milk fortifier of  claim 19 , wherein the human milk oligosaccharide is lacto-N-fucopentaose. 
     
     
         27 . The human milk fortifier of  claim 19 , wherein the human milk oligosaccharide is present in an amount of 0.01 mg/mL to 5 mg/mL. 
     
     
         28 . A method of reducing inflammation in an infant, toddler, or child in need thereof, the method comprising administering to the infant, toddler, or child a nutritional composition comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, and from 40 mg/L to 185 mg/L of total long chain omega-3 fatty acids. 
     
     
         29 . The method of  claim 28 , wherein the nutritional composition further comprises from 0.001 μg/mL to 5 μg/mL of a carotenoid. 
     
     
         30 . The method of  claim 29 , wherein the carotenoid is selected from the group consisting of lutein, lycopene, beta-carotene, and combinations thereof.