US2018125937A1PendingUtilityA1
Modified nucleoside, nucleotide, and nucleic acid compositions
Est. expiryDec 16, 2031(~5.4 yrs left)· nominal 20-yr term from priority
Inventors:Antonin De FougerollesKristy M. WoodSayda M. ElbashirNoubar B. AfeyanPedro ValenciaJason P. Schrum
A61P 37/02A61P 9/10A61P 3/10A61P 9/00A61P 35/00A61P 25/28A61P 3/00C12P 21/00C07K 2/00A61K 9/0019A61K 9/1271A61K 9/1647A61K 31/7105A61K 9/1272C12N 15/88A61K 48/0041A61K 48/0066A61K 48/00C12N 15/117A61K 9/0024C07K 14/535A61K 48/005A61K 9/16A61K 9/14A61K 48/0033A61K 9/0048A61K 31/7088A61K 38/193A61K 38/4833C12N 15/00C12P 21/02C12N 15/67A61K 31/7115
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Claims
Abstract
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
Claims
exact text as granted — not AI-modified1 . A method of producing a polypeptide of interest in a mammalian cell or tissue, the method comprising, contacting said mammalian cell or tissue with a formulation comprising a modified mRNA encoding the polypeptide of interest, wherein the formulation is selected from the group consisting of nanoparticles, poly(lactic-co-glycolic acid) (PLGA) microspheres, lipidoid, lipoplex, liposome. Polymers, carbohydrates (including simple sugars), cationic lipids, fibrin gel, fibrin hydrogel, fibrin glue, fibrin sealant, fibrinogen, thrombin, rapidly eliminated lipid nanoparticles (reLNPs) and combinations thereof.
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