US2018118680A1PendingUtilityA1

Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators

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Assignee: GENENTECH INCPriority: Oct 11, 2013Filed: Dec 21, 2017Published: May 3, 2018
Est. expiryOct 11, 2033(~7.2 yrs left)· nominal 20-yr term from priority
Inventors:Huifen ChenYanyan ChuSteven DoAnthony A. EstradaBaihua HuAleksandr KolesnikovXingyu LinJoseph P. LyssikatosDaniel ShoreVishal VermaLan WangGuosheng WuPo-Wai Yuen
A61P 43/00A61P 29/02A61P 25/04A61P 29/00A61P 25/02A61P 27/16A61P 1/04A61P 11/06A61P 25/00A61P 11/00A61P 17/04A61P 1/00A61P 13/02A61P 19/02A61P 11/14A61P 11/08C07D 417/12C07D 405/14C07D 401/14C07D 403/14C07D 401/12C07D 403/12A61K 31/4025A61K 31/506C07D 491/048C07D 207/48C07D 451/02A61K 31/4155C07D 417/14
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Claims

Abstract

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A compound selected from: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The compound of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         3 . The compound of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         4 . The compound of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         5 . The compound of  claim 1 , wherein the compound is 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof.

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