Liquid compositions capable of foaming and including active agents, and methods for making or developing same

Abstract

A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein the liquid composition is capable of mechanically foaming without an additional propellant; and wherein upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement. Also provided herein are methods of making disclosed compositions and methods of use.

What is claimed is: 
     
         1 . A foam applicator comprising:
 a liquid composition suitable for topical use, wherein the liquid composition comprises:
 4 wt. % and 15 wt. % of a phospholipid foaming agent, wherein the phospholipid foaming agent comprises 50 wt. % to 95 wt. % phosphatidyl choline in relation to the dry substance of the phospholipid foaming agent; 
 5 wt. % to 15 wt. % isopropanol, and 
 a pharmaceutically acceptable active agent; 
   wherein the foam applicator is capable of mechanically foaming the liquid composition without an additional propellant; and   wherein mechanical foaming of 250 ml of the liquid composition using the SITA method results in a foam with a foam volume of about 450 ml to about 1400 ml.   
     
     
         2 . The foam applicator of  claim 1 , wherein upon mechanical foaming of the foam at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement; and wherein the foam has a density of 0.05 g/ml to 0.8 g/ml. 
     
     
         3 . The foam applicator of  claim 1 , further comprising between 2 wt. % and 25 wt. % propylene glycol. 
     
     
         4 . The foam applicator according to  claim 1 , wherein the liquid composition comprises a solvent selected from the group consisting of water, monovalent alcohol, polyalcohol, and mixtures thereof. 
     
     
         5 . The foam applicator according to  claim 1 , wherein the pharmaceutically acceptable active agent is selected from the group consisting of local anesthetics, antimycotics, antibiotics, analgesics, nonsteroidal antirrheumatics, nonsteroidal anti-inflammatories, corticoids, immune modulators, and salts thereof. 
     
     
         6 . The foam applicator according to  claim 1  wherein the active agent is selected from the group consisting of diclofenac, ketoprofen, and ibuprofen. 
     
     
         7 . The foam applicator according to  claim 6 , wherein the liquid composition comprises between 0.1 wt. % and 20 wt. % of the active agent. 
     
     
         8 . The foam applicator according to  claim 1 , wherein the phospholipid foaming agent comprises at most 15 wt. % of lyso-phosphatidyl choline, at most 10 wt. % of phosphatidic acid and at most 10 wt. % of phosphatidyl ethanolamine. 
     
     
         9 . A method for treatment of pain, inflammation, rheumatic diseases or acute trauma, comprising applying a foam to the skin of a warm-blooded mammal in need thereof, wherein the foam is created by mechanically foaming using the foam applicator according to  claim 1  immediately prior to the application, whereby the composition contains as active ingredient at least one analgesic.