Fgfr1 agonists and methods of use

Abstract

The invention provides nucleic acid molecules encoding anti-fibroblast growth factor receptor-1 (FGFR1) antibodies and vectors and host cells comprising the nucleic acid molecules.

What is claimed is: 
     
         1 . A nucleic acid molecule encoding an anti-fibroblast growth factor receptor-1 (FGFR1) antibody, wherein the antibody binds to peptide #26 KLHAVPAAKTVKFKCP (SEQ ID NO: 28) or peptide #28 FKPDHRIGGYKVRY (SEQ ID NO: 29) and wherein the antibody is a human, humanized, or chimeric antibody. 
     
     
         2 . A nucleic acid molecule encoding an anti-FGFR1 antibody, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence GFTFTSNWIS (SEQ ID NO: 9), (b) HVR-H2 comprising an amino acid sequence selected from the group consisting of AEIDPYDGATDYADSVKG (SEQ ID NO: 14) and EIDPYDGATDYADSVKG (SEQ ID NO: 15), and (c) HVR-H3 comprising an amino acid sequence selected from the group consisting of TGTDVMDY (SEQ ID NO: 19) and GTDVMDY (SEQ ID NO: 20). 
     
     
         3 . The nucleic acid molecule of  claim 2 , further comprising (a) HVR-L1 comprising the amino acid sequence RASQDVSTAVA (SEQ ID NO: 21); (b) HVR-L2 comprising the amino acid sequence SASFLYS (SEQ ID NO: 22); and (c) HVR-L3 comprising the amino acid sequence QQSYTTPPT (SEQ ID NO: 23). 
     
     
         4 . The nucleic acid molecule of  claim 1 , wherein the antibody is a multispecific antibody. 
     
     
         5 . The nucleic acid molecule of  claim 4 , wherein the antibody also binds to beta-Klotho. 
     
     
         6 . The nucleic acid molecule of  claim 2 , wherein the antibody is a multispecific antibody. 
     
     
         7 . The nucleic acid molecule of  claim 6 , wherein the antibody also binds to beta-Klotho. 
     
     
         8 . The nucleic acid molecule of  claim 3 , wherein the antibody is a multispecific antibody. 
     
     
         9 . The nucleic acid molecule of  claim 8 , wherein the antibody also binds to beta-Klotho. 
     
     
         10 . The nucleic acid molecule of  claim 1 , wherein the antibody is an IgG1 antibody. 
     
     
         11 . The nucleic acid molecule of  claim 2 , wherein the antibody is an IgG1 antibody. 
     
     
         12 . The nucleic acid molecule of  claim 3 , wherein the antibody is an IgG1 antibody. 
     
     
         13 . A vector comprising the nucleic acid molecule of any one of  claims 1 - 12 . 
     
     
         14 . A host cell comprising the vector of  claim 13 .