Hydrogel-forming material, premix, and hydrogel formation method

Abstract

A hydrogel-forming material, a premix, and a method for forming a hydrogel through a simple process at room temperature. The material including: a disperse phase (A) including a lipid peptide-based gelator including at least one of a compound of Formula (1) or pharmaceutically usable salt thereof, water, and a fatty acid salt; and a phase (B) that includes a water-soluble acidic polymer: (where R1 is a C9-23 aliphatic group, R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a C1-2 branched chain, R3 is a —(CH2)n-X group, n is a number of 1 to 4, X is an amino group, a guanidino group, a —CONH2 group, a 5-membered ring optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s)).

1 . A premix for preparation of a hydrogel for use in a cosmetic or a quasi drug, the premix comprising:
 a lipid peptide-based gelator consisting of at least one of a compound of Formula (1) or a pharmaceutically usable salt thereof;   water; and   a fatty acid salt:   
       
         
           
           
               
               
           
         
       
       (where R 1  is a C 9-23  aliphatic group, R 2  is a hydrogen atom or a C 1-4  alkyl group that optionally has a C 1-2  branched chain, R 3  is a —(CH 2 ) n —X group, n is a number of 1 to 4, X is an amino group, a guanidino group, a —CONH 2  group, a 5-membered ring optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s)).