Medical analysis system

Abstract

The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.

1 . A medical analysis system for pre-clinical and/or clinical analysis of data obtained from at least one patient, the system comprising:
 an internal database (IDB), the database comprising a collection of data, analysis results, flow definitions, and tool definitions, and other related data for tools that utilize a database repository,   a database access unit (DA), the unit being adapted for providing access to the internal database,   a flow definition unit (FD), the unit providing execution of a configurable flow of analysis and visualization of a plurality of data modalities, the plurality of data modalities comprising:   a first bio-molecular modality comprising bio-molecular data related to the patient, and   a second clinical modality comprising clinical data related to the patient,   a tool execution engine (TEE), having an interface for the system to configure and instantiate one or more tools working on one or more of the data modalities,   a tool repository, the repository comprising a collection of tools for which the system is configured to execute, said tools complying with a set of rules in order for it to be possible to visualize their execution in a graphical user interface (GUI),   one or more associated external databases (EDB), the external database(s) representing data stored in the said system itself, or in a database different from the said internal database (IDB), and   a graphical user interface (GUI), said interface simultaneously visualizing data, analysis results, and outcome of one or more tool executions, and wherein said interface is further adapted for simultaneously visualizing:   
       1) an outcome of said first bio-molecular modality, and 
       2) an outcome of said second clinical modality. 
     
     
         2 . The medical analysis system according to  claim 1 , wherein the medical analysis system is applied to at least one patient in an in pre-clinical situation. 
     
     
         3 . The medical analysis system according to  claim 1 , wherein said analysis system is applied to a group of patients. 
     
     
         4 . The medical analysis system according to  claim 1 , wherein said analysis system is applied to one patient in a clinical situation. 
     
     
         5 . The medical analysis system according to  claim 1 , wherein the medical analysis system is a functioning as a clinical decision support system (CDS). 
     
     
         6 . The medical analysis system according to  claim 1 , wherein said first bio-molecular modality and said second clinical modality is integrateable by a machine learning algorithm, the result of said integration being visualizable in the graphical user interface. 
     
     
         7 . The medical analysis system according to  claim 1 , wherein said first bio-molecular modality and said second clinical modality is integrateable by a statistical algorithm, the result of said integration being visualizable in the graphical user interface. 
     
     
         8 . The medical analysis system according to  claim 1 , wherein said first bio-molecular modality and said second clinical modality is integrateable based on their respective genomic annotation, the result of said integration being visualizable in the graphical user interface. 
     
     
         9 . The medical analysis system according to  claim 1 , wherein said first bio-molecular modality is based on a high-throughput data sampling modality 
     
     
         10 . The medical analysis system according to  claim 9 , wherein the sample provided by said high-throughput data sampling modality comprise data on at least 100.000 parameter/species. 
     
     
         11 . The medical analysis system according to  claim 1 , wherein said first bio-molecular modality is selected from the group consisting of a high-throughput gene expression profiling, DNA methylation status profiling, comparative genomic hybridization analysis. 
     
     
         12 . The medical analysis system according to  claim 1 , wherein said flow definition unit (FD) comprises at least one further bio-molecular modality 
     
     
         13 . The medical analysis system according  claim 1 , wherein said further bio-molecular modality is selected from the group consisting of a high-throughput gene expression profiling, DNA methylation status profiling, comparative genomic hybridization analysis, and SNP profile. 
     
     
         14 . The medical analysis system according to  claim 13 , wherein said patient has a clinical condition selected from the group consisting cancer, a cardiovascular disease, a metabolic disease, a gastro-intestinal disease, a neurological disease. 
     
     
         15 . A process for the discovery of bio-molecular or clinical signature associated with a specific clinical condition comprising the use of the medical analysis system according to  claim 1 . 
     
     
         16 . The process according to  claim 15 , wherein the clinical condition is selected from the group consisting of cancer, a cardiovascular disease, a metabolic disease, a gastro-intestinal disease, a neurological disease. 
     
     
         17 . The process according to  claim 16 , wherein said cancer is breast cancer or colon cancer. 
     
     
         18 . The process according to  claim 1 , wherein said signature is a gene expression signature, DNA methylation status signature, comparative genomic hybridization signature and SNP signature. 
     
     
         19 . A process for clinical decision support comprising the use of the medical analysis system according to  claim 1 . 
     
     
         20 . The process according to  claim 19 , wherein the data of a patient is applied to the system for identification of a bio-molecular or clinical signature associated with a clinical condition. 
     
     
         21 . A computer program a product being adapted to enable a computer system comprising at least one computer having data storage means associated therewith to control an medical analysis system according to  claim 1 .