Methods of tracking skin conditions using cyclolignan compounds

Abstract

The present invention includes compositions and methods for the treatment of skin conditions by administration of a cyclolignan such as picropodophyllin and/or a derivative, metabolite, analog, prodrug, pharmaceutically acceptable salt, or hydrate thereof.

1 .- 18 . (canceled) 
     
     
         19 . A method of treating a skin condition selected from verruca (warts), condyloma, molluscum contagiosum, human papilloma virus infection (HPV), herpes simplex virus infection, acanthosis nigricans, seborrheic keratosis, fibroepithelial polyp (skin tag), lentigo, psoriasis, dermatitis, ichthyosis, acne vulgaris, and melasma; in a patient in need thereof, the method comprising administering to the patient a composition comprising a therapeutically effective amount of picropodophyllin and/or a salt, or hydrate thereof. 
     
     
         20 . The method of  claim 19 , wherein the composition is formulated for topical administration to the patient's skin. 
     
     
         21 . The method of  claim 19 , wherein the composition is formulated for administration by one or more of the following routes: oral, subcutaneous, intravenous, intramuscular, and/or nasal inhalation. 
     
     
         22 . The method of  claim 19 , wherein the composition comprising a therapeutically effective amount of picropodophyllin contains from about 0.1 to 5% (weight/volume) of picropodophyllin. 
     
     
         23 . The method of  claim 22 , wherein the composition contains from about 0.5 to 2.5% (weight/volume) of picropodophyllin. 
     
     
         24 . The method of  claim 23 , wherein the composition contains from about 0.5 to 2.0% (weight/volume) of picropodophyllin. 
     
     
         25 . The method of  claim 19 , wherein the composition further comprises a solvent selected from: ethanol, isopropanol, chloroform, DMSO, glacial acetic acid, hot fatty oils, and ether, and combinations thereof. 
     
     
         26 . The method of  claim 19 , wherein the composition comprising a therapeutically effective amount of picropodophyllin further comprises an ingredient selected from: benzoine tincture, hard paraffin, soft paraffin, microcrystalline wax, ceresine, wool fat, beeswax, emulsifying wax, cetrimide, N,N-dimethylacetamide, benzyl alcohol, polyvinylpyrrolidone, hydroxypropylcellulose, polyethylene glycol, methylcellulose, propylene glycol, olive oil, coconut oil, sesame oil, almond oil, peanut oil, polyoxyethylated castor oil, dehydrated alcohol, white petrolatum, water, and combinations thereof.