Salts of hiv inhibitor compounds

Abstract

The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to process and intermediates useful for preparing such salts.

1 - 32 . (canceled) 
     
     
         33 . A solid oral dosage form comprising darunavir and a therapeutically effective amount of a succinate salt of the compound of formula I: 
       
         
           
           
               
               
           
         
       
     
     
         34 . The solid oral dosage form of  claim 33 , further comprising an additional therapeutic agent. 
     
     
         35 . The solid oral dosage form of  claim 34 , wherein the additional therapeutic agent is an HIV integrase inhibitor. 
     
     
         36 . The solid oral dosage form of  claim 33 , wherein the dosage form comprises 10 mg to 30 mg of the succinate salt of the compound of formula I. 
     
     
         37 . The solid oral dosage form of  claim 33 , further comprising at least one excipient selected from lactose, microcrystalline cellulose, crosscarmellose sodium, magnesium stearate, povidone, and lactose monohydrate. 
     
     
         38 . The solid oral dosage form of  claim 33 , wherein the dosage form is a tablet. 
     
     
         39 . A method of treating HIV infection, comprising administering to a human being in need thereof (a) darunavir and (b) a therapeutically affective amount of a succinate salt of the compound formula I: 
       
         
           
           
               
               
           
         
       
     
     
         40 . The method of  claim 39 , wherein the darunavir and the succinate salt of the compound of formula I are administered simultaneously, concurrently, separately, or sequentially. 
     
     
         41 . The method of  claim 39 , wherein of the succinate salt of the compound of formula I is administered at a dosage of 10 mg to 30 mg. 
     
     
         42 . The method of  claim 39 , further comprising administering to the human being an HIV integrase inhibitor.