Use of trpc6 mrna levels in peripheral blood cells for early detection/diagnosis of senile dementia

Abstract

The invention relates to the use of TRPC6 mRNA levels in peripheral blood cells for the early detection/diagnosis of senile dementia. Specifically, the present invention provides a classic transient receptor potential channel 6 (TRPC6) gene or protein thereof and the use of same in preparing a reagent or test kit for detecting or diagnosing Alzheimer's disease. The present invention further relates to a polypeptide used to prepare a medicament that treats AD, and relates to a composition of said polypeptide.

1 - 18 . (canceled) 
     
     
         19 . A kit for diagnosis of Alzheimer's disease (AD), the kit comprising:
 (a) a nucleic acid chip for measuring the level of nucleic acids encoding TRPC6 and/or a pair of primers for measuring the level of nucleic acids encoding TRPC6; and   (b) instructions for using the nucleic acid chip and/or pair of primers for diagnosing AD.   
     
     
         20 . The kit of  claim 19 , further comprising (c) a reagent. 
     
     
         21 . The kit of  claim 20 , wherein the reagent is a reagent for extracting total RNA from peripheral blood cells. 
     
     
         22 . The kit of  claim 20 , wherein the reagent is a reagent for performing an amplification assay. 
     
     
         23 . The kit of  claim 22 , wherein the reagent for performing an amplification assay is selected from the group consisting of a primer, a reverse transcriptase, and a polymerase. 
     
     
         24 . The kit of  claim 19 , wherein the pair of primers consists of SEQ ID NO:1 and SEQ ID NO: 2. 
     
     
         25 . The kit of  claim 19 , wherein the AD is early AD. 
     
     
         26 . The kit of  claim 19 , wherein the AD is mild cognitive impairment (MCI).