Carrier for oromucosal administration of physiologically active substances

Abstract

The invention relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer ( 1 ) of polymer nanofibres workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer ( 1 ) of polymer nanofibres a drug and/or other physiologically active substance are deposited in a releasable manner.

1 . A carrier for oromucosal administration of physiologically active substances to a subject, comprising at least one flexible layer of polymer nanofibres produced by needleless electrostatic spinning;
 wherein the at least one flexible layer of polymer nanofibres is adapted for contact and adhesion with a sublingual surface of a mouth cavity of the subject;   wherein the at least one flexible layer of polymer nanofibres is workable according to a shape of the sublingual surface;   wherein the at least one flexible layer of polymer nanofibres comprises a drug and/or other physiologically active substance deposited in a releasable manner.   
     
     
         2 . The carrier of  claim 1 , further comprising a covering layer that overlaps a first side of the at least one flexible layer of polymer nanofibres, and the covering layer is adapted to prohibit leaching of the releasable drug and/or other physiologically active substance from the at least one flexible layer of polymer nanofibres to outside of the adhesion location and into the mouth cavity. 
     
     
         3 . The carrier of  claim 1 , wherein the drug or other physiologically active substance is a component of the nanofibres. 
     
     
         4 . The carrier of  claim 1 , further comprising at least two flexible layers of polymer nanofibres, wherein the drug and/or other physiologically active substance comprised in two or more of the flexible layers of polymer nanofibres is different. 
     
     
         5 . The carrier of  claim 1 , further comprising at least two flexible layers of polymer nanofibres, wherein each of the at least two flexible layers of polymer nanofibres comprises a different drug and/or other physiologically active substance. 
     
     
         6 . The carrier of  claim 1 , further comprising at least two flexible layers of polymer nanofibres, wherein each of the at least two flexible layers of polymer nanofibres comprises the drug and/or other physiologically active substance, and wherein each of the at least two flexible layers of polymer nanofibres is adapted to provide a different rate of release of the drug and/or other physiologically active substance. 
     
     
         7 . The carrier of  claim 6 , wherein the drug and/or other physiologically active substance comprises one or more different drugs and/or other physiologically active substances. 
     
     
         8 . The carrier of  claim 1 , further comprising at least two flexible layers of polymer nanofibres, wherein each of the at least two flexible layers of polymer nanofibres comprises the drug and/or other physiologically active substance, and wherein two or more of the at least two flexible layers of polymer nanofibres is adapted to provide a different rate of release of the drug and/or other physiologically active substance. 
     
     
         9 . The carrier of  claim 8 , wherein the drug and/or other physiologically active substance comprises one or more different drugs and/or other physiologically active substances. 
     
     
         10 . The carrier of  claim 1 , wherein the drug or other physiologically active substance is impregnated into the at least one flexible layer of polymer nanofibers. 
     
     
         11 . The carrier of  claim 4 , wherein the drug or other physiologically active substance is impregnated between the at least two flexible layers of polymer nanofibers.