System and method of attaching soft tissue to an implant

Abstract

One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

1 - 20 . (canceled) 
     
     
         21 . An implant comprising:
 a metal surface comprising a nano-textured surface formed by anodizing the metal surface.   
     
     
         22 . The implant accord to  claim 21 , wherein the implant is a metal implant. 
     
     
         23 . The implant according to  claim 21 , comprising one or more layers on the metal surface selected from the group consisting of:
 a calcified material layer or calcification-inducing layer coating in contact with the nano-textured surface; and   a bioactive scaffold layer comprising a biocompatible polymer matrix and a bioactive agent, wherein at least a portion of the scaffold layer is in contact with the calcified material layer or calcification-inducing layer, where said calcified material layer or calcification-inducing layer is present.   
     
     
         24 . The implant according to  claim 21 , wherein the nano-textured surface comprises one or more bioactive agents or biocompatible inorganic materials. 
     
     
         25 . The implant according to  claim 24 , wherein the one or more bioactive agents or biocompatible inorganic materials comprise an antimicrobial agent. 
     
     
         26 . The implant according to  claim 21 , wherein the metal surface comprises titanium or a titanium alloy. 
     
     
         27 . The implant according to  claim 26 , wherein the metal surface comprises titanium. 
     
     
         28 . The implant according to  claim 26 , wherein the nano-textured surface comprises one or more bioactive agents or biocompatible inorganic materials. 
     
     
         29 . The implant according to  claim 27 , wherein the nano-textured surface comprises one or more bioactive agents or biocompatible inorganic materials. 
     
     
         30 . The implant according to  claim 28 , wherein the one or more bioactive agents or biocompatible inorganic materials comprise an antimicrobial agent. 
     
     
         31 . The implant according to  claim 29 , wherein the one or more bioactive agents or biocompatible inorganic materials comprise an antimicrobial agent. 
     
     
         32 . The implant according to  claim 21 , wherein the nano-textured surface comprises one or more bioactive agents. 
     
     
         33 . The implant according to  claim 21 , wherein the nano-textured surface comprises one or more bioactive agents or biocompatible inorganic materials, wherein at least one of said one or more agents or materials are co-deposited with the nano-textured surface. 
     
     
         34 . The implant according to  claim 21 , wherein the nano-textured surface comprises one or more bioactive agents or biocompatible inorganic materials that is deposited directly onto the nano-textured surface. 
     
     
         35 . The implant according to  claim 34 , wherein the metal surface comprises titanium or a titanium alloy. 
     
     
         36 . The implant according to  claim 33 , wherein the one or more bioactive agents or biocompatible inorganic materials comprises an antimicrobial agent. 
     
     
         37 . The implant according to  claim 36 , wherein the metal surface comprises titanium or a titanium alloy. 
     
     
         38 . The implant according to  claim 21 , wherein said nano-textured surface is a surface, wherein the maximum distance from the highest point to the lowest point of said nano-textured surface is less than 200 nanometers. 
     
     
         39 . The implant according to  claim 21 , wherein the nano-textured surface comprises protrusions having an average height ranging from 20 to 200 nm. 
     
     
         40 . A method of inducing the growth of fibrocartilage tissue and/or bone on an implant to enhance the attachment of the metal implant to a patient's tissues, said method comprising implanting an implant comprising a metal surface comprising a nano-textured surface formed by anodizing the metal surface.