Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

Abstract

Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A 1 , A 2 , R 6 , w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

What is claimed is: 
     
         1 - 55 . (canceled) 
     
     
         56 . A process for preparing a compound of formula 
       
         
           
           
               
               
           
         
         as its hydrochloride salt, comprising: 
         combining 
       
       
         
           
           
               
               
           
         
         and di-tert-butyl dicarbonate in the presence of a base to form 
       
       
         
           
           
               
               
           
         
         resolving 
       
       
         
           
           
               
               
           
         
         into its enantiomers 
       
       
         
           
           
               
               
           
         
         and isolating 
       
       
         
           
           
               
               
           
         
         and deprotecting 
       
       
         
           
           
               
               
           
         
         to obtain 
       
       
         
           
           
               
               
           
         
       
     
     
         57 . A process according to  claim 56 , wherein said resolving is accomplished by chiral HPLC. 
     
     
         58 . A process according to  claim 56 , further comprising combining 
       
         
           
           
               
               
           
         
         with 4-methylbenzenesulfonic acid to obtain 
       
       
         
           
           
               
               
           
         
       
     
     
         59 . A process according to  claim 58 , further comprising combining 
       
         
           
           
               
               
           
         
         with lithium diisopropylamide to form a mixture, then combining the mixture with tert-butyl methyl (2-oxoethyl)carbamate to obtain 
       
       
         
           
           
               
               
           
         
       
     
     
         60 . A process according to  claim 58 , further comprising combining 
       
         
           
           
               
               
           
         
         in 2-bromoethanol to obtain 
       
       
         
           
           
               
               
           
         
       
     
     
         61 . A process for preparing a compound of formula 
       
         
           
           
               
               
           
         
         as its hydrochloride salt, comprising: 
         a) combining 
       
       
         
           
           
               
               
           
         
       
       in 2-bromoethanol to obtain 
       
         
           
           
               
               
           
         
         b) combining 
       
       
         
           
           
               
               
           
         
       
       with lithium diisopropylamide to form a mixture, then combining the mixture with tert-butyl methyl(2-oxoethyl)carbamate to obtain 
       
         
           
           
               
               
           
         
         c) combining 
       
       
         
           
           
               
               
           
         
       
       with 4-methylbenzenesulfonic acid to obtain 
       
         
           
           
               
               
           
         
       
       and
 d) combining 
 
       
         
           
           
               
               
           
         
       
       and di-tert-butyl dicarbonate in the presence of a base to form 
       
         
           
           
               
               
           
         
         e) resolving 
       
       
         
           
           
               
               
           
         
       
       into its enantiomers 
       
         
           
           
               
               
           
         
       
       and isolating 
       
         
           
           
               
               
           
         
       
       and
 f) deprotecting 
 
       
         
           
           
               
               
           
         
       
       to obtain 
       
         
           
           
               
               
           
         
       
     
     
         62 . A process according to  claim 61 , wherein said resolving in step e) is accomplished by chiral HPLC.