Compositions and Methods for Managing or Improving Bone Disorders, Cartilage Disorders, or Both

Abstract

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

1 - 69 : (canceled) 
     
     
         70 . A method for increasing bone density in a mammal in need thereof comprising administering a therapeutically effective amount of a composition comprising a mixture of  Morus  extract enriched for at least one prenylated flavonoid and at least one stilbene, and an  Acacia  extract enriched for at least one flavan. 
     
     
         71 . The method of  claim 70 , wherein the at least one prenylated flavonoid is Albanin G, Kuwanon G, Morusin, or any combination thereof. 
     
     
         72 . The method of  claim 70 , wherein the at least one stilbene is oxyresveratrol, mulberroside A, or a combination thereof. 
     
     
         73 . The method of  claim 70 , wherein the active ingredients in the  Acacia  extract are catechin, epicatechin, or a combination thereof. 
     
     
         74 . The method of  claim 70 , wherein the composition additionally comprises a glucosamine-type compound. 
     
     
         75 . The method of  claim 74 , wherein the glucosamine-type compound comprises glucosamine sulfate, glucosamine hydrochloride, N-acetylglucosamine, chondroitin sulfate methylsulfonylmethane, and hyaluronic acid. 
     
     
         76 . The method of  claim 70 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable carrier, diluent, or excipient, wherein the pharmaceutical or nutraceutical formulation comprises from about 0.5 weight percent (wt %) to about 90 wt % of active ingredients of the extract mixture. 
     
     
         77 . The method of  claim 76 , wherein the composition is formulated as a tablet, hard capsule, softgel capsule, powder, or granule. 
     
     
         78 . A method for increasing bone density in a mammal in need thereof comprising administering a therapeutically effective amount of a composition comprising a mixture of a  Morus  extract enriched for one or more prenylated flavonoids, and an  Uncaria  extract enriched for flavans. 
     
     
         79 . The method of  claim 78 , wherein the  Morus  extract is from  Morus alba , and the  Uncaria  extract is from  Uncaria gambir.    
     
     
         80 . The method of  claim 78 , wherein the  Morus  extract is enriched for Albanin G, Kuwanon G, Morusin, oxyresveratrol, mulberroside A, or any combination thereof. 
     
     
         81 . The method of  claim 78 , wherein the major active ingredients in the  Uncaria  extract is catechin, epicatechin, or a combination thereof. 
     
     
         82 . The method of  claim 78 , wherein the composition additionally comprises a glucosamine-type compound. 
     
     
         83 . The method of  claim 82 , wherein the glucosamine-type compound is selected from the group consisting of glucosamine sulfate, glucosamine hydrochloride, N-acetylglucosamine, chondroitin sulfate and methylsulfonylmethane, and hyaluronic acid. 
     
     
         84 . The method of  claim 78 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable carrier, diluent, or excipient, wherein the pharmaceutical or nutraceutical formulation comprises from about 0.5 weight percent (wt %) to about 90 wt % of active ingredients of the extract mixture. 
     
     
         85 . The method of  claim 84 , wherein the composition is formulated as a tablet, hard capsule, softgel capsule, powder, or granule.