Compositions and methods for increasing lifespan and health span

Abstract

Disclosed herein are compounds, extracts, and active fractions of the plant Geum japonicum and methods for increasing longevity and survival potency or for preventing or treating various medical conditions, including diabetes, inflammation, wound healing, bed sores, and ocular disorders. The compounds provided herein can be formulated into pharmaceutical compositions and medicaments that are useful in the disclosed methods. Also provided are the use of the compounds and extracts in preparing pharmaceutical formulations and medicaments

1 .- 13 . (canceled) 
     
     
         14 . A method for preventing or treating diabetes in a subject in need thereof, the method comprising administering to the subject an effective amount of an organic extract of  Geum japonicum.    
     
     
         15 . A method for preventing or treating an ocular disease or condition in a subject in need thereof, the method comprising administering to the subject an effective amount of an organic extract of  Geum japonicum.    
     
     
         17 . A method for enhancing wound healing in a subject having a wound, the method comprising administering to the subject an effective amount of an organic extract of  Geum japonicum.    
     
     
         18 . The method of  claim 17 , wherein the wound is a bed sore. 
     
     
         19 . The method of  claim 17 , wherein the organic extract is an ethanol extract. 
     
     
         20 . The method of  claim 17 , wherein the organic extract is a methanol extract. 
     
     
         21 . The method of  claim 17 , wherein the subject is a human. 
     
     
         22 . The method of  claim 17 , wherein the extract of is administered orally. 
     
     
         23 . The method of  claim 17 , wherein the extract is administered by subcutaneous injection, intramuscular injection, or intravenous infusion. 
     
     
         24 . The method of  claim 17  wherein the extract is administered in an amount of from 0.01 mg/kg/day to 2000 mg/kg/day. 
     
     
         25 . The method of  claim 17 , wherein the effective amount of the extract is a formulation comprising the extract and a pharmaceutically acceptable carrier.