Biological Fluid Separation Device and Biological Fluid Separation and Testing System

Abstract

A biological fluid separation device that is adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid separation device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid separation device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid separation device of the present disclosure also provides a closed separation and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid separation device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid separation device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.

What is claimed is: 
     
         1 . A biological fluid separation device adapted to receive a multi-component blood sample, the biological fluid separation device comprising:
 a separation cartridge having an inlet port and a flow channel defined within the cartridge in fluid communication with the inlet port, the flow channel containing a separation element adapted to separate the multi-component blood sample into at least a first component and a second component, a first collection chamber defined within the cartridge in fluid communication with the flow channel and including a first outlet port, and a second collection chamber defined within the cartridge in fluid communication with the flow channel and including a second outlet port, the second collection chamber isolated from the first collection chamber.   
     
     
         2 . The biological fluid separation device of  claim 1 , wherein the first component is a cellular portion of the multi-component blood sample and the second component is a plasma portion of the multi-component blood sample. 
     
     
         3 . The biological fluid separation device of  claim 1 , wherein the separation element comprises a plurality of posts. 
     
     
         4 . The biological fluid separation device of  claim 1 , wherein the flow channel has a spiral shape. 
     
     
         5 . The biological fluid separation device of  claim 1 , further comprising an inlet channel in fluid communication with the inlet port and the flow channel, the inlet channel comprising a sample stabilizer. 
     
     
         6 . The biological fluid separation device of  claim 1 , wherein the second component is a plasma portion of the multi-component blood sample. 
     
     
         7 . The biological fluid separation device of  claim 1 , wherein the first collection chamber is adapted to receive at least a portion of the second component therein and the second collection chamber is adapted to receive at least a portion of the first component. 
     
     
         8 . The biological fluid separation device of  claim 7 , wherein the first component is a cellular portion of the multi-component blood sample and the second component is a plasma portion of the multi-component blood sample. 
     
     
         9 . The biological fluid separation device of  claim 8 , wherein the cellular portion is prevented from entering the first collection chamber. 
     
     
         10 . The biological fluid separation device of  claim 1 , wherein at least a portion of the flow channel comprises a sample stabilizer. 
     
     
         11 . The biological fluid separation device of  claim 10 , wherein the second component is a plasma portion of the multi-component blood sample. 
     
     
         12 . The biological fluid separation device of  claim 1 , wherein the inlet port is adapted to receive the multi-component blood sample via connection to a blood collection device. 
     
     
         13 . The biological fluid separation device of  claim 1 , wherein the first outlet port is adapted for connection to a point-of-care testing device for closed transfer of a portion of the second component of the multi-component blood sample from the first collection chamber to the point-of-care testing device. 
     
     
         14 . The biological fluid separation device of  claim 13 , wherein a portion of the biological fluid separation device is adapted for connection with a drive device, wherein with the drive device connected to the biological fluid separation device, the drive device causes flow of the second component of the multi-component blood sample from the first collection chamber to the point-of-care testing device.