Compound use in promoting energy expenditure

Abstract

The present invention provides a compound of structural formula (1), a salt thereof for use in promoting energy expenditure and/or thermogenesis.

1 . A compound of structural formula 1: 
       
         
           
           
               
               
           
         
         or a salt thereof for use in promoting energy expenditure and/or thermogenesis. 
       
     
     
         2 . A compound according to  claim 1  wherein the compound is for use in promoting carbohydrate burning. 
     
     
         3 . A compound according to  claim 1  wherein the compound is for use in attaining or maintaining weight loss in a subject. 
     
     
         4 . A compound according to  claim 1  wherein the compound is for use in the treatment or prevention of obesity or an obesity related disorder. 
     
     
         5 . A compound according to  claim 3  wherein the compound is used to reduce fat mass and substantially maintain lean mass. 
     
     
         6 . A compound according to  claim 1  wherein the compound is for use in maintaining body temperature in a subject. 
     
     
         7 . A compound according to  claim 1  for use in improving stamina in a subject. 
     
     
         8 . A compound according to  claim 1  for use in improving an exercise effect. 
     
     
         9 . A compound for use according to  claim 1  wherein the compound has the structural formula 1a: 
       
         
           
           
               
               
           
         
       
     
     
         10 . A composition comprising a compound of formula 1 or 1a as an active agent for use in accordance with any preceding claim. 
     
     
         11 . A composition according to  claim 10  wherein the composition is selected from the group consisting of a food product, a food extract, drink, food additive, nutritional supplement, medical food, pet food product and a powdered nutritional formulation to be reconstituted in milk or water. 
     
     
         12 . A food or food extract enriched with a compound of formula 1 or 1a. 
     
     
         13 . A food or food extract according to  claim 11  wherein the food extract is derived from coffee, sea buckthorn, bilberry, whortleberry, blueberry, kiwifruit, tamarillo, prune, crowberry, cranberry, peach, apple, sunflower, mayhaw, tea, grapes, black current, medlar, babaco, blackberry, bartlett pear, orange, lemon, citrus, cocoa, quince, chicory, feijoa, pear, sweet potato, japanese persimmon, tomato, banana, pineapple, olive, cherry, pepino, prickly pear, fenugreek, bitter melon or red chicory. 
     
     
         14 . A food or food extract according to  claim 13  wherein the food extract is derived from a fermented product. 
     
     
         15 . A food or food extract according to  claim 14  wherein the fermented product is vinegar or fermented tea. 
     
     
         16 . A pharmaceutical or nutraceutical composition comprising a compound of formula 1 or 1a. 
     
     
         17 . A diet product for use as part of a low calorie diet for weight loss, wherein the diet product comprises a compound of formula 1 or 1a. 
     
     
         18 . Use of a compound of formula 1 or 1a in the preparation of a product for promoting energy expenditure, promoting thermogenesis, improving stamina and/or improving an exercise effect. 
     
     
         19 . Use of a compound of formula 1 or 1a in the preparation of a diet product. 
     
     
         20 . A method for promoting energy expenditure, promoting thermogenesis, improving stamina and/or improving an exercise effect comprising administering compound of formula 1 or 1a to a subject.