Immunologically active phyto-mixture and its use in the prevention and in a method for treatment of efflorescences

Abstract

The present invention relates to an immunologically active phyto-mixture comprising at least one plant extract selected from the family a) Asteraceae, b) Verbenaceae, and/or c) Burseraceae, preferably at least one plant extract from the genus a) Bidens , b) Stachytarpheta , and/or c) Bursera . Particularly preferred species include a) Bidens alba, Bidens pilosa , b) Stachytarpheta jamaicensis, Stachytarpheta cayennensis, Stachytarpheta indica , and/or c) Bursera simaruba, Bursera microphylla, Bursera glabrifolia . The phyto-mixture optionally comprises d) at least one further biologically active plant extract, such as Aloe vera and/or Stemodia maritima . The afore-mentioned phyto-mixture according to the invention exhibits good antimicrobial and anti-inflammatory efficiency and is particularly suitable for prevention and treatment of efflorescences. Therefore, the present invention also relates to a preparation for oral and topical administration for prevention and treatment of efflorescences of the skin and the mucous membrane.

1 . Immunologically active phyto-mixture which exhibits antimicrobial efficiency against transient skin flora and anti-inflammatory efficiency, wherein the phyto-mixture comprises at least one ethanolic plant extract selected from
 a)  Bidens alba  ( Bid. alba ),  Bidens pilosa  ( Bid. pilosa ) from genus  Bidens  of the Asteraceae family, and at least one further ethanolic plant extract, selected from   b)  Stachytarpheta jamaicensis  ( Sta. jamaicensis ),  Stachytarpheta cayennensis  ( Sta. cayennensis ),  Stachytarpheta indica  ( Sta. indica ) from genus  Stachytarpheta  of the Verbenaceae family, and/or   c)  Bursera simaruba  ( Bur. simaruba ),  Bursera microphylla  ( Bur. microphylla ) and  Bursera glabrifolia  ( Bur. glabrifolia ) from genus  Bursera  of the Burseraceae family.   
     
     
         2 . Phyto-mixture according to  claim 1 , characterised in that it further comprises:
 d) at least one further extract of a biologically active plant comprising  Aloe  species of genus  Aloe  of the Asphodeloideae subfamily, species of genus  Stemodia  of the Plantaginaceae family and/or  Stemodia maritima.      
     
     
         3 . Phyto-mixture according to  claim 1 , which comprises three or more ethanolic plant extracts, selected from:
 a) and c) and d);   a) and b) and d); or   a), b) and c) and d),   wherein d) respectively is  Stemodia maritima.      
     
     
         4 . Phyto-mixture according to  claim 1 , characterised in that the phyto-mixture further comprises d) at least one further plant extract of an  Aloe  species of the genus  Aloe  of subfamily Asphodeloideae. 
     
     
         5 . Phyto-mixture according to  claim 1 , characterised in that the transient skin flora comprises  Staphylococcus, Streptococcus , methicillin-resistant  Staphylococcus aureus  (MRSA), Pseudomonads and/or Acinetobacteria. 
     
     
         6 . Phyto-mixture according  claim 1 , characterised in that the phyto-mixture comprises an antibacterial efficiency at a concentration of greater than or equal to 10 μg/ml to less than or equal to 10 mg/ml measured as minimal inhibitory concentration (MHK/MIC) and/or as minimum bactericidal concentration (MBK/MBC) of the respective extract mixture. 
     
     
         7 . Phyto-mixture according  claim 1 , characterised in that the phyto-mixture exhibits an anti-inflammatory efficiency at less than or equal to 200±10 μg/ml measured as IC 50  of 5-LOX inhibition of the respective extract mixture. 
     
     
         8 . Phyto-mixture according to  claim 1 , characterised in that the phyto-mixture comprises at least one of the compounds comprising flavonoids, saponins, iridoids, phenolic acids, polyphenols, polysaccharides, glycosylases, terpenes, monoterpenes, sesquiterpene lactones, proazulenes, sulfides, carotenoids, vitamins A B C D E, amino acids, and/or minerals. 
     
     
         9 . Phyto-mixture according to  claim 1 , characterised in that the phyto-mixture is present in
 liquid form comprising solution, dispersion, suspension, emulsion, tincture, syrup, juice, and tea   solid form comprising tablet, powder, powder, dragee, globules, granules and lyophilisate, capsule, or   as mixture comprising capsules, aerosol, spray, emulsion, lotion, and cream.   
     
     
         10 . Phyto-mixture according to  claim 1 , characterised in that the phyto-mixture in liquid form, depending on the alternative, has a pH tolerated by the skin greater than or equal to 3 to less than or equal to 9, a pH tolerated by the oral mucosa greater than or equal to 6 to less than or equal to 8, a pH tolerated by the nasal mucosa greater than or equal to 5 to less than or equal to 7, or a pH tolerated by the eye greater than or equal to 7 to less than or equal to 9. 
     
     
         11 . Phyto-mixture according to  claim 1 , characterised in that the liquid phyto-mixture is present as tincture, comprising
 greater than or equal to 1% by weight of at least one ethanolic plant extract selected from a)  Bid. alba, Bid. pilosa , and one further ethanolic plant extract, selected from b)  Sta. jamaicensis, Sta. cayennensis, Sta. indica , and/or c)  Bur. simaruba, Bur. microphylla, Bur. glabrifolia , based on the total content of the tincture (T=100% by weight),   at least one acidifier comprising acetic acid, citric acid, ascorbic acid, adipic acid, tartaric acid, mandelic acid, and/or malic acid,   greater than or equal to 1% by weight of an  Aloe  extract, based on the total content of the tincture (T=100% by weight),   wherein the tincture has a pH value of greater than or equal to 3 to less than or equal to 9 and the tincture is an aqueous/ethanolic mixture having an ethanol concentration greater than or equal to 70%, based on the total composition of the tincture.   
     
     
         12 . A method for the production of an immunologically active phyto-mixture according to  claim 1  comprising the steps of
 providing at least one plant part of at least one plant selected from a) and one further plant selected from b) and/or c), respectively above- and/or underground plant parts; 
 respectively at least one extraction step, wherein aqueous ethanol, ethanol, greater than or equal to 70% ethanol to less than or equal to 100% ethanol is used as solvent; and 
 obtaining at least one ethanolic plant extract of the respective plant; 
 optionally one further processing step comprising drying, comminution, grinding using a mill, processing in a mortar, dispersing; and 
 mixing at least two of the ethanolic plant extracts, one being selected from a) and the at least second one of b) and/or c); and 
 optionally adding a third plant extract selected from b), c) and/or d). 
 
     
     
         13 . Method according to  claim 12 , wherein the at least two plant extracts are obtained in liquid form, in dry form or as mixture of solid and liquid forms. 
     
     
         14 . Immunologically active phyto-mixture according to  claim 1  and/or produced according to  claim 12  for use as medicament, medical product, nutritional supplement, cosmetic, and/or as an immunologically active addition to one of the afore-mentioned products. 
     
     
         15 . Pharmaceutic or cosmetic composition comprising the immunologically active phyto-mixture according to  claim 1 . 
     
     
         16 . Immunologically active-phyto-mixture for use in the prevention or treatment of efflorescences comprising at least one ethanolic plant extract selected from:
 a)  Bid. alba, Bid. pilosa  of the Asteraceae family and at least one further ethanolic plant extract, selected from,   b)  Sta. jamaicensis, Sta. cayennensis, Sta. indica  of the Verbenaceae family, and/or   c)  Bur. simaruba, Bur. microphylla  and/or  Bur. glabrifolia  of the Burseraceae family.   
     
     
         17 . Phyto-mixture for use according to  claim 16 , which comprises three or more plant extracts, selected from
 a) and c) and d);   a) and b) and d); or   a), b) and c) and d),   wherein d) respectively is  Stemodia maritima      
     
     
         18 . Phyto-mixture for use according to  claim 16 , characterised in that efflorescences comprise cosmetic or pathologic efflorescences, skin diseases associated with the transient skin flora, bacterial and/or viral infections of the skin, furunculoses, mycoses, inflammatory reactions of the skin, impetigo, benign and malign tumor formation, dermatoses, eczemas, pruritus, psoriasis, acne, skin irritations, erythema, symptomatical efflorescences, burns, chemical burns, frostbites, efflorescences occurring by toxins, medicaments, drugs, allergens, radiation and as side effect, irritations and inflammations of the skin caused by bites and stings of insects and parasites. 
     
     
         19 . Phyto-mixture for use according to  claim 16 , characterised in that the phyto-mixture is present as
 oral formulation comprising i) solid forms, such as tablet, powder, granules, effervescent tablet, dry syrup, dragee, globules, capsule and lyophilisate, ii) liquid forms, such as suspension, solution, dispersion, tincture, concentrate, tea, or iii) mixture, such as spray, aerosol, or   topical formulation comprising i) solid forms, such as powder, bath additive, hip bath powder, ii) liquid forms, such as suspension, emulsion, solution, dispersion, tincture, tea, or iii) mixture, such as spray, aerosol, lotion, semi-solid forms comprising ointments, creams and pastes.   
     
     
         20 . Phyto-mixture for use according to  claim 16 , characterised in that the phyto-mixture is present as tincture, comprising
 greater than or equal to 1% by weight of at least one ethanolic plant extract selected from  Bid. alba, Bid. pilosa , and at least one further ethanolic plant extract, selected from  Sta. jamaicensis, Sta. cayennensis, Sta. indica  and/or  Bur. simaruba , based on the total content (T=100% by weight) of the tincture,   at least one acidifier selected from acetic acid, citric acid, ascorbic acid, adipic acid, tartaric acid, mandelic acid and/or malic acid,   greater than or equal to 1% by weight of an  Aloe  extract, based on the total content of the tincture (T=100% by weight), and   at least one excipient,   wherein the tincture has a pH value greater than or equal to 3 to less than or equal to 9 and the tincture is an aqueous/ethanolic mixture, having an ethanol concentration greater than or equal to 70%, based on the total composition of the tincture.   
     
     
         21 . Phyto-mixture for use according to  claim 16 , characterised in that the oral formulation is based on a solid form, wherein
 the solid form comprises at least one dried ethanolic plant extract, selected from  Bid. alba, Bid. pilosa , and at least one further dried ethanolic plant extract, selected from  Sta. jamaicensis, Sta. cayennensis  and/or  Sta. indica, Bur. simaruba  and optionally  Aloe,      the at least one plant extract is contained in a content of greater than or equal to 1% by weight, based on the total content of the solid form (F=100% by weight),   the residual moisture is less than or equal to 5% by weight, based on the total content of the dry plant extract (F=100% by weight) and   at least one excipient is contained.   the at least one plant extract is contained in a content of greater than or equal to 1% by weight, based on the total content of the solid form (F=100% by weight),   the residual moisture is less than or equal to 5% by weight, based on the total content of the dry plant extract (F=100% by weight) and   at least one excipient is contained.