Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin

Abstract

Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

1 . A method for improving neurological health of an animal comprising: administering a therapeutically effective amount of a composition to an animal, wherein the composition comprises one or more of psilocybin, psilocin, baeocystin, norbaeocystin, salts thereof, or combinations thereof, one or more of erinacines, hericenones or combinations thereof, and niacin. 
     
     
         2 . The method of  claim 1 , wherein the animal is a human. 
     
     
         3 . The method of  claim 1 , wherein the composition additionally improves memory and cognition. 
     
     
         4 . The method of  claim 1 , wherein the composition additionally improves motor skills and coordination. 
     
     
         5 . The method of  claim 1 , wherein the composition additionally improves ability to solve complex computer coding challenges. 
     
     
         6 . The method of  claim 1 , wherein the composition additionally improves hearing. 
     
     
         7 . The method of  claim 1 , wherein the composition additionally improves vision. 
     
     
         8 . The method of  claim 1 , wherein the composition additionally improves sensory function. 
     
     
         9 . The method of  claim 1 , wherein the composition additionally improves learning. 
     
     
         10 . The method of  claim 1 , wherein the composition additionally promotes neurogenesis. 
     
     
         11 . The method of  claim 1 , wherein the composition additionally comprises one or more of ( Bacopa monnieri ), Gotu kola ( Centella asiatica ),  Gingko  ( Gingko biloba ), Ginger ( Zingiber officinale ), Holy Basil ( Ocimum sanctum ), Hu Zhang ( Polygonum cuspidatum ), Oregano ( Origanum vulgare, Origanum onites ), Rosemary ( Rosmarinus officinalis, Rosmarinus eriocalyx, Rosmarinus  species), Turmeric ( Curcuma longa ), Green Tea ( Camellia sinensis ), lavender ( Lavandula spica  and  Lavandula  species), skullcap ( Scutellaria lateriflora ), oat straw ( Avena sativa  and  Avena byzantine ), Diviner's Sage ( Salvia divinorum ), ayahuasca ( Banisteriopsis caapi  and  Psychotria  species),  Tabernanthe iboga, Voacanga africana, Tabernaemontana undulate , peyote ( Lophophora williamsii ), morning glory ( Ipomoea tricolor, Argyreia nervosa ),  Cannabis sativa, Cannabis indica  or  Cannabis ruderalis , or combinations thereof. 
     
     
         12 . The method of  claim 1 , wherein the composition additionally comprises one or more mycelium of  Antrodia, Beauveria, Copelandia, Cordyceps, Ganoderma, Grifola, Hericium, Inonotus, Isaria, Panaeolus  or  Phellinus  fungi, or combinations thereof; one or more extract of mycelium of  Antrodia, Beauveria, Copelandia, Cordyceps, Ganoderma, Grifola, Hericium, Inonotus, Isaria Panaeolus  or  Phellinus , or combinations; one or more extract of  Antrodia, Beauveria, Copelandia, Cordyceps, Ganoderma, Grifola, Hericium, Inonotus, Isaria, Panaeolus  or  Phellinus  fruitbodies, or combinations thereof; or combinations thereof. 
     
     
         13 . The method of  claim 1  wherein the composition comprises one or more of extracted, isolated, synthetic or manufactured active compound, or combinations thereof. 
     
     
         14 . A method for improving neurological health comprising: administering a daily dose of a composition for at least one month to a patient, wherein the composition comprises: one or more of about 0.1 to 10 mg of psilocybin, psilocin, baeocystin, norbaeocystin, or salts thereof, one or more of about 0.1 to 1 gram of psilocybin mushrooms, or combinations thereof; about 0.1 to 200 mg of one or more of erinacines, hericenones, or combinations thereof; and about 1 to 200 mg of niacin. 
     
     
         15 . The method of  claim 14 , wherein the composition comprises about 0.6 to 10 mg of one or more of psilocybin, psilocin, baeocystin, norbaeocystin, salts thereof, or combinations thereof, about 20 to 200 mg of one or more of erinacines, hericenones, or combinations thereof, and about 50 to 200 mg of niacin. 
     
     
         16 . The method of  claim 14 , wherein the composition comprises about 0.9 to 10 mg of one or more of psilocybin, psilocin, baeocystin, norbaeocystin, salts thereof, or combinations thereof, about 50 to 200 mg of one or more of erinacines, hericenones, or combinations thereof, and about 50 to 200 mg of niacin. 
     
     
         17 . The method of  claim 14 , wherein the composition additionally comprises one or more of ( Bacopa monnieri ), Gotu kola ( Centella asiatica ),  Gingko  ( Gingko biloba ), Ginger ( Zingiber officinale ), Holy Basil ( Ocimum sanctum ), Hu Zhang ( Polygonum cuspidatum ), Oregano ( Origanum vulgare, Origanum onites ), Rosemary ( Rosmarinus officinalis, Rosmarinus eriocalyx, Rosmarinus  species), Turmeric ( Curcuma longa ), Green Tea ( Camellia sinensis ), lavender ( Lavandula spica  and  Lavandula  species), skullcap ( Scutellaria lateriflora ), oat straw ( Avena sativa  and  Avena byzantine ), Diviner's Sage ( Salvia divinorum ), ayahuasca ( Banisteriopsis caapi  and  Psychotria  species),  Tabernanthe iboga, Voacanga africana, Tabernaemontana undulate , peyote ( Lophophora williamsii ), morning glory ( Ipomoea tricolor, Argyreia nervosa ),  Cannabis sativa, Cannabis indica  or  Cannabis ruderalis , or combinations thereof. 
     
     
         18 . A method for improving neurological health of an animal comprising: administering a therapeutically effective amount of a composition to an animal, wherein the composition comprises: one or more of erinacines, hericenones, or combinations thereof; niacin; and one or more of N,N-dimethyltryptamine, 5-hydroxytryptamine, 5-hydroxytryptophan, 4-acetoxy-N,N-dimethyltryptamine, 4-acetoxy-N-methyl-N-ethyltryptamine, 4-acetoxy-N,N-diethyltryptamine, 4-acetoxy-N-methyl-N-propyltryptamine, 4-acetoxy-N-methyl-N-isopropyltryptamine, 4-acetoxy-N,N-dipropyltryptamine, 4-acetoxy-N,N-diisopropyltryptamine, 4-hydroxy-N-methyl-N-ethyltryptamine, 4-hydroxy-N-methyl-N-propyltryptamine, 4-hydroxy-N-methyl-N-isopropyltryptamine, 4-hydroxy-N, N-diisopropyltryptamine, 4-hydroxy-N,N-diisopropyltryptamine, 4-hydroxy-N-methyl-N-propyltryptamine, 4-hydroxy-N,N-diethyltryptamine, 4-hydroxy-N,N-diallyltryptamine, N-methyl-N-ethyltryptamine, N,N-diethyltryptamine, N,N-dipropyltriptamine, N,N-diisopropyltryptamine, N-methyl-N-propyltryptamine, N-methyl-N-isopropyltryptamine, a-methyl-tryptamine, N-ethyl-N-isopropyltryptamine, N-methyl-N-butyl-tryptamine, N,N-dimethyl-5-hydroxytryptamine, 5-methoxy-a-methyltryptamine, 5-methoxy-N,N-dimethyltryptamine, 5-methoxy-N,N-diethyltryptamine, 5-methoxy-N,N-dipropyltryptamine, 5-methoxy-N,N-diisopropyltryptamine, 5-methoxy-N-ethyl-N-isopropyltryptamine, 2,a-dimethyltryptamine, a,N-dimethyltryptamine, a-ethyltryptamine, 2-methyl-N, N-dimethyltryptamine, 2-methyl-N,N-diethyltryptamine, 1-methylpsilocin, ibogaine, 4-hydroxindole-3-acetylaldehyde, 4-hydroxtryptophol, 4-hydroxindole-3-acetic acid, salts thereof, or combinations thereof. 
     
     
         19 . The method of  claim 17 , wherein the animal is a human. 
     
     
         20 . The method of  claim 17 , wherein the composition additionally results in one or more of improved memory and cognition, improved motor skills and coordination, improved ability to solve complex computer coding challenges, improved hearing, improved vision, improved sensory function, improved learning or promotion of neurogenesis, or combinations thereof.