US2018015117A1PendingUtilityA1
Method for prevention of colectomy
Est. expiryNov 25, 2031(~5.3 yrs left)· nominal 20-yr term from priority
A61P 37/02A61P 37/00A61P 1/04C12N 2310/17A61K 45/06A61K 31/713C12N 15/117C12N 2320/31A61K 39/0005C12N 2310/315
51
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Claims
Abstract
A method of treating chronic active ulcerative colitis in a subject that is refractory or responds insufficiently or is intolerant to anti-inflammatory therapy, comprises administering to a patient in need thereof an effective exposure of an oligonucleotide comprising the sequence 5′-GGAACAGTTCGTCCATGGC-3′ (SEQ ID NO.2), wherein at least one CG dinucleotide is unmethylated. The oligonucleotide is not administered with corticosteroids or glucocorticosteroids.
Claims
exact text as granted — not AI-modified1 . A method of treating chronic active ulcerative colitis in a subject that is refractory or responds insufficiently or is intolerant to anti-inflammatory therapy, comprising administering to a patient in need thereof an effective exposure of an oligonucleotide comprising the sequence 5′-GGAACAGTTCGTCCATGGC-3′ (SEQ ID NO.2), wherein at least one CG dinucleotide is unmethylated, and wherein said oligonucleotide is not administered with corticosteroids or glucocorticosteroids.
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