Temperature Insensitive In Vivo Analyte Devices, Methods and Systems

Abstract

Disclosed herein are membrane structures for use in analyte sensors, where the membrane structures exhibit low temperature sensitivity.

1 .- 55 . (canceled) 
     
     
         56 . An analyte sensor comprising:
 a working electrode comprising:
 an enzyme layer proximate a surface of the working electrode; and 
 a membrane proximate the enzyme layer, wherein the membrane comprises:
 a polymer comprising a heterocycle-containing component; and 
 a polyetheramine crosslinker; and 
 
   a counter electrode.   
     
     
         57 . The analyte sensor of  claim 56 , wherein the heterocyle-containing component comprises an aromatic heterocycle. 
     
     
         58 . The analyte sensor of  claim 56 , where the heterocycle-containing component is a heterocyclic nitrogen containing component. 
     
     
         59 . The analyte sensor of  claim 58 , wherein the polymer comprises a heterocyclic nitrogen containing component is a poly(4-vinylpyridine-co-styrene) polymer. 
     
     
         60 . The analyte sensor of  claim 56 , wherein the polyetheramine crosslinker is a monoamine polyetheramine. 
     
     
         61 . The analyte sensor of  claim 56 , wherein the polyetheramine crosslinker is a polyamine polyetheramine. 
     
     
         62 . (canceled) 
     
     
         63 . (canceled) 
     
     
         64 . The analyte sensor of  claim 56 , wherein the polyetheramine crosslinker comprises a polyethylene oxide component and polypropylene oxide component. 
     
     
         65 . The analyte sensor of  claim 64 , wherein the molar ratio of the polypropylene oxide component and the polyethylene oxide component is from 1:35 to 35:1. 
     
     
         66 . The analyte sensor of  claim 65 , wherein the molar ratio of the polypropylene component oxide to polyethylene oxide component is 29:6. 
     
     
         67 . The analyte sensor of  claim 65 , wherein the molar ratio of the polypropylene oxide component to polyethylene oxide component is 1:2. 
     
     
         68 . The analyte sensor of  claim 56 , wherein the polyetheramine crosslinker further comprises a multi-arm branch component. 
     
     
         69 . The analyte sensor of  claim 68 , wherein the polyetheramine crosslinker comprises a 3-arm branching component. 
     
     
         70 . The analyte sensor of  claim 68 , wherein the polyetheramine crosslinker comprises a 4-arm branching component. 
     
     
         71 . The analyte sensor of  claim 68 , wherein the multi-arm branch component is a polyethylene glycol multi-arm epoxide. 
     
     
         72 . The analyte sensor of  claim 68 , wherein the multi-arm branch component is triglycidyl glycerol ether. 
     
     
         73 . The analyte sensor of  claim 56 , wherein the polyetheramine crosslinker has a molecular weight from 500 daltons to 5000 daltons. 
     
     
         74 . The analyte sensor of  claim 73 , wherein the polyetheramine crosslinker has a molecular weight of 2000 daltons. 
     
     
         75 . The analyte sensor of  claim 59 , wherein the poly(4-vinylpyridine-co-styrene) polymer comprises a compound of the formula: 
       
         
           
           
               
               
           
         
         wherein x and y are each positive integers. 
       
     
     
         76 . The analyte sensor of  claim 75 , wherein the ratio of x and y is from 1:1 and 5:1. 
     
     
         77 . The analyte sensor of  claim 76 , wherein the ratio of x and y is 4:1. 
     
     
         78 . The analyte sensor of  claim 56 , wherein the polyetheramine crosslinker comprises a compound of the formula: 
       
         
           
           
               
               
           
         
         wherein n and m are each positive integers. 
       
     
     
         79 . The analyte sensor of  claim 56 , wherein the crosslinker further comprises a polyethylene glycol copolymer. 
     
     
         80 . The analyte sensor of  claim 56 , wherein the membrane comprises a compound of the formula: 
       
         
           
           
               
               
           
         
         wherein 
         x and z are each independently integers ranging from 1 to 2000; and 
         a, m and n are each independently integers ranging from 1 to 100. 
       
     
     
         81 . The analyte sensor of  claim 56 , wherein the analyte sensor is configured such that a signal from the analyte sensor changes 5%/° C. or less over a range of temperatures. 
     
     
         82 . The analyte sensor of  claim 81 , wherein the analyte sensor is configured such that a signal from the analyte sensor changes 1%/° C. or less over a range of temperatures. 
     
     
         83 . The analyte sensor of  claim 56 , wherein the membrane is configured to limit flux of analyte to the enzyme layer. 
     
     
         84 . The analyte sensor of  claim 56 , wherein the enzyme layer comprises a glucose-responsive enzyme. 
     
     
         85 . The analyte sensor of  claim 84 , wherein the glucose-responsive enzyme comprises glucose oxidase. 
     
     
         86 . The analyte sensor of  claim 56 , wherein the enzyme layer comprises a redox mediator. 
     
     
         87 . The analyte sensor of  claim 86 , wherein the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex. 
     
     
         88 .- 416 . (canceled)