Triple antibiotic cationic ointment

Abstract

The present disclosure generally relates to petrolatum-based compositions for suspension of active ingredients and methods for forming stable suspensions of active ingredients in petrolatum, and more specifically to compositions of triple antibiotic cationic ointments. In particular, the present disclosure relates to a method for suspension of antibiotics and biocides in petrolatum at room temperature and a petrolatum-based composition having a stable suspension of active ingredients including antibiotics and biocides.

What is claimed is: 
     
         1 . A composition for a triple antibiotic cationic ointment comprising:
 a petrolatum base;   at least one antibiotic powder, the at least one antibiotic powder mixed into the petrolatum base to form an ointment; and   at least one biocide solution, wherein the at least one biocide is added in nanodroplets to the ointment forming a stable suspension.   
     
     
         2 . The petrolatum-based composition of  claim 1 , wherein the at least one antibiotic powder includes neomycin sulfate, bacitracin zinc, and polymixin b. 
     
     
         3 . The petrolatum-based composition of  claim 2 , wherein the concentration of each of the antibiotic powders per gram of petrolatum includes 3.5 mg of neomycin, 400 units of bacitracin zinc, and 5,000 units of polymixin b. 
     
     
         4 . The petrolatum-based composition of  claim 1 , wherein the at least one biocide is a cationic quaternary ammonium. 
     
     
         5 . The petrolatum-based composition of  claim 1 , wherein the at least one biocide is PHMB. 
     
     
         6 . The petrolatum-based composition of  claim 1 , wherein the at least one biocide is benzalkonium chloride. 
     
     
         7 . The petrolatum-based composition of  claim 1 , wherein the at least one biocide includes both PHMB and benzalkonium chloride. 
     
     
         8 . A composition for a biocide suspension ointment comprising:
 a petrolatum base;   at least one powder-form ingredient, the at least one powder-form ingredient mixed into the petrolatum base to form an ointment; and   at least one biocide, wherein the at least one biocide is added in nanodroplets to the ointment to form a stable suspension.   
     
     
         9 . The composition for a biocide suspension ointment of  claim 8 , wherein the at least one powder-form ingredient is from the group consisting of neomycin sulfate, polymyxin b, bacitracin, cortisone, cyclosporine, and baking powder. 
     
     
         10 . A method for formulating a petrolatum-based composition comprising:
 (a) mixing at least one powder-form ingredient into a petrolatum base; and   (b) adding nanodroplets of a liquid biocide solution to the mixture, wherein the nanodroplets are suspended in a stable triple antibiotic cationic ointment.   
     
     
         11 . The method for formulating a petrolatum-based composition of  claim 10 , wherein the powder-form ingredient is one of an antibiotic powder, a cortisone powder, a cyclosporine powder, or a baking soda powder. 
     
     
         12 . The method for formulating a petrolatum-based composition of  claim 10 , wherein the liquid biocide solution consists of cationic biocides. 
     
     
         13 . The method for formulating a petrolatum-based composition of  claim 10 , wherein the powder-form ingredient is the baking soda powder and the liquid biocide solution is an anionic sodium hypochlorite.