US2018008541A1PendingUtilityA1
Cyclodextrin Compositions Encapsulating a Selective ATP Inhibitor and Uses Thereof
Est. expiryJan 14, 2034(~7.5 yrs left)· nominal 20-yr term from priority
Inventors:Jean-Francois GeschwindShanmugasundaram Ganapathy-KanniappanSurojit SurBert VogelsteinKenneth W. Kinzler
A61P 35/00A61K 45/06C08B 37/0012A61K 31/19A61K 47/6951A61K 47/40A61K 9/146A61K 9/08C08L 5/16A61K 31/02C08B 37/0015A61K 9/19
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Claims
Abstract
The invention provides compositions comprising cyclodextrins encapsulating a selective ATP inhibitor, as well as uses thereof.
Claims
exact text as granted — not AI-modified1 . A composition comprising a cyclodextrin and a pharmaceutical agent represented in the general formula:
wherein, independently of each occurrence:
X represents a halide, a sulfonate, a carboxylate, an alkoxide, or an amine oxide;
R 1 represents OR, H, N(R″) 2 , C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, or C6-C12 heteroaryl;
R″ represents H, C1-C6 alkyl, or C6-C12 aryl;
R represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R′; and
R′ represents H, C1-C20 alkyl or C6-C12 aryl,
wherein the cyclodextrin encapsulates the pharmaceutical agent.
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