Oral Care Composition

Abstract

Provided herein is an oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. The composition is effective in accelerating HSP 27 production in damaged tissues of the oral cavity and enhances repair of the damaged tissue.

What is claimed is: 
     
         1 . An oral care composition comprising a basic amino acid or a salt thereof in an amount of from 0.001 weight % to 0.08 weight % by total weight of the composition, and an orally acceptable carrier. 
     
     
         2 . The composition of  claim 1 , wherein the basic amino acid or salt thereof is present in the composition in an amount of from 0.003 weight % to 0.05 weight % by total weight of the composition, or from 0.005 weight % to 0.02% weight % by total weight of the composition, or in an amount of 0.005 weight % by total weight of the composition. 
     
     
         3 . The composition of  claim 1 , wherein the basic amino acid is selected from arginine, lysine, and histidine. 
     
     
         4 . The composition of  claim 1 , wherein the composition is selected from mouthwashes, sprays, dentifrices, oral strips, chewing gums and lozenges. 
     
     
         5 . The composition of  claim 1 , wherein the oral care composition further comprises one or more agents selected from: surfactants, desensitizing agents, whitening agents, tartar control agents, binders, thickening agents, detergents, adhesion agents, foam modulators, pH modifying agents, mouth feel agents, sweeteners, flavorants, colorants, humectants, fluoride sources and combinations thereof. 
     
     
         6 . The composition of  claim 1 , wherein the composition comprises the basic amino acid in a free form and is substantially free of any salts of the basic amino acid. 
     
     
         7 . The composition of  claim 1  for use in preventing or repairing soft tissue damage in an oral cavity, or for use in healing a wound in a tissue of an oral cavity, or for use in preventing or treating inflammation in a tissue of an oral cavity, or for use in reducing reactive oxygen species in a tissue of an oral cavity. 
     
     
         8 . The composition for use according to  claim 7 , wherein the use comprises increasing or accelerating HSP 27 expression in the tissue. 
     
     
         9 . The composition for use according to  claim 7 , wherein the tissue is gingival tissue. 
     
     
         10 . The composition for use according to  claim 7 , wherein the use comprises contacting the oral cavity with the composition for a period of at least 30 seconds, at least 1 minute, at least 5 minutes, at least 10 minutes, at least 15 minutes or at least 1 hour. 
     
     
         11 . A method of increasing or accelerating HSP 27 in a tissue of an oral cavity comprising administering to the tissue a composition according to  claim 1 . 
     
     
         12 . The method of  claim 11 , wherein the method comprises preventing or repairing soft tissue damage in the oral cavity, or wherein the method comprises healing a wound in the tissue of the oral cavity, or wherein the method comprises preventing or treating inflammation in the tissue of the oral cavity, or wherein the method comprises reducing reactive oxygen species in the tissue of the oral cavity. 
     
     
         13 . The method of  claim 11 , wherein the tissue is gingival tissue. 
     
     
         14 . The method of any of  claim 11  comprising contacting the oral cavity with the composition for a period of at least 30 seconds, at least 1 minute, at least 5 minutes, at least 10 minutes, at least 15 minutes or at least 1 hour. 
     
     
         15 . (canceled) 
     
     
         16 . (canceled) 
     
     
         17 . (canceled) 
     
     
         18 . A method of increasing or accelerating HSP 27 in a tissue of an oral cavity comprising administering to the tissue an effective amount of a basic amino acid or a salt thereof. 
     
     
         19 . The method of  claim 18 , wherein the method comprises preventing or repairing soft tissue damage in the oral cavity, or comprises healing a wound in the tissue of the oral cavity or comprises preventing or treating inflammation in the tissue of the oral cavity, or comprises reducing reactive oxygen species in the tissue of the oral cavity. 
     
     
         20 . The method of  claim 18 , wherein the tissue is gingival tissue.