Method for calibrating a device for measuring the concentration of creatinine

Abstract

A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

1 . A method for calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising:
 receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions;   receiving outputs of the measuring device at an end time;   calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and   determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.   
     
     
         2 . The method of  claim 1 , wherein the measuring device includes a sensor for measuring creatine in one or more of the calibration solutions. 
     
     
         3 . The method of  claim 1 , wherein the measuring device includes a sensor for measuring creatinine in one or more of the calibration solutions. 
     
     
         4 . The method of  claim 1 , wherein the measuring device includes a sensor for measuring creatine and creatinine in one or more of the calibration solutions. 
     
     
         5 . The method of  claim 1 , wherein the measuring device is an amperometric measuring device. 
     
     
         6 . The method of  claim 1 , further comprising determining the temperature model by receiving measurements of the changes in temperature of the calibration solutions from a temperature probe from the initial time to the end time. 
     
     
         7 . The method of  claim 6 , wherein said received measurements are recorded measurements. 
     
     
         8 . The method of  claim 6 , wherein said determining the temperature model comprises calibrating the received measurements of the changes in temperature with a second temperature probe. 
     
     
         9 . The method of  claim 1 , wherein the determining a relationship between the measuring device outputs and the calculated concentrations of Cr and Crn comprises calculating sensor sensitivities of the measuring devices. 
     
     
         10 . The method of  claim 9 , further comprising receiving temperature measurements after the end time and updating the calculated sensitivities of the measuring devices using the temperature measurements received after the end time. 
     
     
         11 . The method of  claim 1 , wherein the end time is greater than 14 days after the initial time. 
     
     
         12 . A computer readable medium comprising instructions which when executed by one or more processors of an electronic device, cause the electronic device to operate in accordance with the method as claimed in  claim 1 . 
     
     
         13 . An electronic device comprising:
 one or more processors; and   memory comprising instructions which when executed by one or more of the one or more processors cause the electronic device to operate in accordance with the method claimed in  claim 1 .   
     
     
         14 . A package comprising one or more calibration solutions, the package containing instructions for use with the method of  claim 1 . 
     
     
         15 . The package of  claim 14  further comprising an indication of the initial time and the concentrations at the initial time of Cr and/or Crn of the one or more calibration solutions. 
     
     
         16 . The package of  claim 14 , further comprising a temperature probe for measuring the temperatures of the creatinine solutions from the initial time to the end time, and memory for storing the measured temperatures. 
     
     
         17 . A package comprising one or more calibration solutions, the package containing instructions for use with the electronic device of  claim 13 . 
     
     
         18 . The package of  claim 17 , further comprising an indication of the initial time and the concentrations at the initial time of Cr and/or Crn of the one or more calibration solutions. 
     
     
         19 . The package of  claim 17 , further comprising a temperature probe for measuring the temperatures of the creatinine solutions from the initial time to the end time, and memory for storing the measured temperatures.