Foamable Vehicle and Pharmaceutical Compositions Thereof

Abstract

A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

1 .- 21 . (canceled) 
     
     
         22 . A hygroscopic composition comprising:
 a diol;   a water gelling agent in an amount ranging from about 0.1% to about 5% by weight; and   an antibiotic agent in an amount ranging from about 0.1% to about 5% by weight,   wherein the composition is suitable for topical administration, and   wherein the hygroscopic composition has an Aw value of less than about 0.9.   
     
     
         23 . The hygroscopic composition of  claim 22 , wherein the diol comprises propylene glycol. 
     
     
         24 . The hygroscopic composition of  claim 22 , wherein the antibiotic agent comprises a tetracycline antibiotic or a derivative, ester, salt, or a mixture thereof 
     
     
         25 . The hygroscopic composition of  claim 24 , wherein the tetracycline antibiotic agent comprises minocycline or a derivative, ester, salt, or a mixture thereof. 
     
     
         26 . The hygroscopic composition of  claim 25 , wherein the minocycline is minocycline hydrochloride. 
     
     
         27 . The hygroscopic composition of  claim 24 , further comprising an antibiotic metal. 
     
     
         28 . The hygroscopic composition of  claim 24 , further comprising an active herbal extract. 
     
     
         29 . The hygroscopic composition of  claim 28 , wherein the active herbal extract is from eucalyptus. 
     
     
         30 . The hygroscopic composition of  claim 24 , wherein the water gelling agent comprises hydroxypropyl cellulose. 
     
     
         31 . The hygroscopic composition of  claim 24 , further comprising one or more additional components. 
     
     
         32 . The hygroscopic composition of  claim 31 , wherein the one or more additional components comprises at least one preservative. 
     
     
         33 . The hygroscopic composition of  claim 32 , wherein the preservative comprises a bisulfite. 
     
     
         34 . The hygroscopic composition of  claim 31 , wherein the one or more additional components comprises a skin penetration enhancer. 
     
     
         35 . The hygroscopic composition of  claim 31 , wherein the one or more additional components comprises a fragrance. 
     
     
         36 . The hygroscopic composition of  claim 31 , wherein the one or more additional components comprises a protectant. 
     
     
         37 . The hygroscopic composition according to  claim 24 , further comprising an essential oil. 
     
     
         38 . The hygroscopic composition of  claim 24 , further comprising a surface active agent in an amount ranging from about 0.2% to about 5% by weight. 
     
     
         39 . The hygroscopic composition of  claim 24 , further comprising a liquefied or compressed gas propellant in an aerosol container in an amount ranging from about 3% to about 25% by weight of the total composition, wherein upon release from the container, a foam suitable for topical administration is formed. 
     
     
         40 . The hygroscopic composition of  claim 24 , further comprising less than about 5% ethanol. 
     
     
         41 . The hygroscopic composition according to  claim 24 , wherein:
 the diol is propylene glycol;   the water gelling agent is hydroxypropyl cellulose; and   the tetracycline antibiotic is minocycline hydrochloride.   
     
     
         42 . The hygroscopic composition according to  claim 41 , further comprising:
 at least one preservative;   a skin penetration enhancer;   a fragrance; and   a protectant.   
     
     
         43 . The hygroscopic composition according to  claim 41 , further comprising:
 at least one preservative;   a skin penetration enhancer;   a fragrance; and   a metal.   
     
     
         44 . The hygroscopic composition according to  claim 41 , further comprising:
 at least one preservative;   a fragrance; and   a metal.   
     
     
         45 . The hygroscopic composition of  claim 24 , wherein the Aw value ranges from about 0.8 to about 0.9. 
     
     
         46 . The hygroscopic composition according to  claim 24 , wherein the Aw value ranges from about 0.7 to about 0.8. 
     
     
         47 . The hygroscopic composition according to  claim 24 , wherein the Aw value is less than about 0.7. 
     
     
         48 . A hygroscopic composition comprising:
 a diol;   a water gelling agent in an amount ranging from about 0.1% to about 5% by weight; and   an antibiotic agent in an amount ranging from about 0.1% to about 5% by weight,   wherein the composition is suitable for topical administration,   wherein the composition does not contain a surface-active agent, and   wherein the hygroscopic composition comprises less than about 2% water.