Intraarticular application of pepstatin in the case of arthrosis

Abstract

The present invention relates to pharmaceutical preparations and medicaments for intraarticular administration, comprising pepstatin, and to the preparation and use thereof, in particular in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia, particularly preferably in arthrosis.

1 . A pharmaceutical preparation formulated for intraarticular administration for the treatment and/or prophylaxis of physiological and/or pathological conditions selected from the group consisting of arthrosis, traumatic cartilage injury, arthritis, pain, allodynia or hyperalgesia, comprising pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios, and at least one or more excipients and/or adjuvants wherein the pharmaceutical preparation is formulated for administration weekly to yearly. 
     
     
         2 . The pharmaceutical preparation according to  claim 1 , comprising at least one further pharmaceutically active compound. 
     
     
         3 . A process for the preparation of a pharmaceutical preparation formulated for intraarticular administration according  claim 1 , wherein pepstatin and/or one of its physiologically acceptable salts, solvates, prodrugs and stereoisomers, including mixtures thereof in all ratios, is brought into a suitable dosage form together with a solid, liquid or semi-liquid excipient or adjuvant and optionally a further medicament active compound. 
     
     
         4 . A method for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, selected from the group consisting of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia and hyperalgesia, comprising intraarticular administration to a patient in need of said treatment of a pharmaceutical preparation of  claim 1 , wherein the pharmaceutical preparation is administered weekly to yearly. 
     
     
         5 .- 9 . (canceled) 
     
     
         10 . The pharmaceutical preparation of  claim 1 , wherein the preparation is administered fortnightly to half-yearly. 
     
     
         11 . The pharmaceutical preparation of  claim 1 , wherein the preparation is administered monthly to quarterly.