US2017348366A1PendingUtilityA1
Method of treating a malignancy in a subject and a pharmaceutical composition for use in same
Est. expiryNov 25, 2019(expired)· nominal 20-yr term from priority
Inventors:Darren Raymond Shafren
A61P 35/04A61P 35/00C12N 2770/32332A61K 35/768C12Q 1/025G01N 33/5011A61K 9/0019C12N 7/00C12N 2770/32371C12N 2770/32333
53
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Claims
Abstract
There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
Claims
exact text as granted — not AI-modified1 . A method of treating abnormal cells in a mammal comprising administering to the mammal an effective amount of a virus capable of infecting the abnormal cells whereby death of the cells is caused and which recognises at least one of a cell adhesion molecule of the immunoglobulin (Ig) superfamily and a complement regulatory protein for infectivity of the abnormal cells.
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