US2017342163A1PendingUtilityA1

ANTI-HtrA1 ANTIBODIES AND METHODS OF USE

52
Assignee: GENENTECH INCPriority: Oct 14, 2011Filed: Jul 18, 2017Published: Nov 30, 2017
Est. expiryOct 14, 2031(~5.2 yrs left)· nominal 20-yr term from priority
Inventors:Yan WuMenno Van Lookeren CampagneDaniel K. KirchhoferMichael T. LipariKenneth KatschkePaul M. MoranScott StawickiWei-Ching Liang
A61P 43/00A61P 9/10A61P 27/02A61P 27/00C07K 2317/92C07K 16/40C07K 2317/76C07K 2317/34A61K 2039/505
52
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Claims

Abstract

The invention provides anti-HtrA1 antibodies and methods of using the same.

Claims

exact text as granted — not AI-modified
1 . An isolated antibody that binds to HtrA1 competitively with an antibody comprising a VH sequence of SEQ ID NO:8 and a VL sequence of SEQ ID NO:7. 
     
     
         2 . The antibody of  claim 1 , wherein competitive binding is determined using an ELISA assay. 
     
     
         3 . An isolated antibody that binds to HtrA1, wherein the antibody (i) binds to an epitope that includes N224, K248, or both of HtrA1, and (ii) inhibits HtrA1 with an IC 50  of ≦30 nM. 
     
     
         4 . The antibody of  claim 3 , wherein the antibody further comprises one or more of the following properties: (i) binds to HtrA1 with a ratio of 1 variable domain to one subunit of an HtrA1 trimer, or (ii) does not prevent trimer formation of HtrA1. 
     
     
         5 . The antibody of  claim 3 , wherein the IC 50  is determined using a serine protease assay with a substrate having SEQ ID NO:12. 
     
     
         6 - 90 . (canceled)

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